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Titanium jaw implant could replace bone grafts in cancer patients

NCT ID NCT00213837

Disease control Sponsor: University Hospital, Strasbourg, France Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This Phase 2 trial tested a new porous titanium implant to rebuild the front part of the jaw after it is removed during cancer surgery. The implant is designed to avoid the need for bone grafts taken from elsewhere in the body, which can cause additional pain and complications. Seven adults participated, and the study looked at how well the implant worked and any complications that occurred.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
porous titanium mandibular prosthesis
What this could lead to
If successful, this implant could offer a simpler, safer way to rebuild the jaw after cancer surgery, reducing the need for complex bone grafts.
What could go wrong
This is a very small early-phase trial with only 7 participants, so results may not apply widely. The implant may fail to integrate or cause complications like infection or rejection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

7 people

The number who actually took part.

Start date

Oct 2003

Finished

Sep 2008

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Male or female more than 18 years old Exclusion Criteria: * Age less than 18 years old * Pregnant women * Local carcinoma excluding radiotherapic or surgical control * Poor general condition * Contraindication to general anesthesia * Uncontrolled diabetes

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Conditions

The condition(s) this trial relates to.

otorhinolaryngologic disease Vocal Cord Paralysis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Otorhinolaryngologic diseases

Contacts and locations

Locations

  • Service d'Oto-Rhino-Laryngologie et de Chirurgie Cervico-Faciale, Hôpital de Hautepierre

    Strasbourg, France

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