New study aims to uncover why COVID-19 harms organs months later
NCT ID NCT06608849
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study follows 345 adults to learn how COVID-19 may cause lasting damage to the lungs, heart, and kidneys. Researchers will compare people who had COVID-19 with those who did not, using blood tests, breathing tests, and heart scans. The goal is to find early warning signs and create guidelines to prevent long-term health problems.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- What this could lead to
- If successful, this could lead to better tools for predicting and preventing long-term organ damage after COVID-19.
- What could go wrong
- This is an observational study, not a treatment trial. It will not test any new drug or therapy, so it cannot directly improve health.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 345 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2024
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
POINT will include patients who have participated in the studies ESCAPE, SAVE, SAVE-MORE and SAVE-LONG. For these patients blood samples and clinical data are already available (Baseline - Year 0 from ESCAPE, SAVE \& SAVE-MORE and Year 1 from SAVE-LONG). POINT needs to enroll three groups of patients (selected by the existing biobank mentioned above, based on the inclusion and exclusion study criteria) to cover the magnitude of the spectrum of COVID-19: * Group A (115 Comparators): Comparators without medical history of acute infection by SARS-CoV-2. * Group B (115 with NO dysfunction): Patients fully recovered by acute COVID-19 who did not present any acute organ injury during acute infection by SARS-CoV-2. * Group C (115 with Dysfunctions): Patients who presented signs of lung, heart, and kidney dysfunction during acute infection by SARS-CoV-2.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Group A (comparators) 1. Adults (18 years or more) of both genders 2. Negative history of acute COVID-19 Group B (patients with ΝΟ dysfunction) 1. Adults (18 years or more) of both genders 2. History of acute COVID-19 hospitalized or non-hospitalized. All cases appearing from start of the pandemic until the last six months may apply 3. Absence of any current overt organ dysfunction 4. Absence of signs of any organ dysfunction during acute COVID-19 Group C (patients with dysfunctions) 1. Adults (18 years or more) of both genders 2. History of acute COVID-19 hospitalized or non-hospitalized. All cases appearing from start of the pandemic until the last six months may apply 3. Presence of signs of organ dysfunction of the lung, the kidneys or the heart during acute COVID-19 Exclusion Criteria: Group A (comparators) 1. Any other co-existing disorder generating clinical symptoms 2. Failure to thrive according to the attending physicians 3. Pregnancy or lactation Group B (patients with ΝΟ dysfunction) 1. Any other co-existing disorder generating clinical symptoms 2. Failure to thrive according to the attending physicians 3. Pregnancy or lactation Group C (patients with dysfunctions) 1. Any other co-existing disorder generating clinical symptoms 2. Medical history of any of: * stage III or IV chronic obstructive pulmonary disease according to the GOLD criteria * pulmonary fibrosis or pulmonary hypertension * stage IV solid tumour malignancy under chemotherapy or radiotherapy * systemic sclerosis * congestive heart failure * stage II, III or IV dyspnoea according to the New York Heart Association classification before the acute COVID-19 3. Limited chance of survival for at least six months due to co-existing comorbidity(-ies) according to the judgement of the attending physicians 4. Pregnancy or lactation
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
6 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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10th Department of Pulmonary Medicine, Sotiria Athens Hospital of Chest Diseases
RECRUITINGAthens, Greece
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1st Department of Internal Medicine, Thriasio General Hospital of Elefsina
RECRUITINGElefsina, Greece
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2nd Department of Internal Medicine, Thriasio General Hospital of Elefsina
RECRUITINGElefsina, Greece
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4th Department of Internal Medicine, ATTIKON University General Hospital
RECRUITINGAthens, Greece
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Obstructive Diseases Clinic, Sotiria Athens Hospital of Chest Diseases
RECRUITINGAthens, Greece
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Out-patient department of Infectious Diseases, Sotiria Athens Hospital of Chest Diseases
RECRUITINGAthens, Greece
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Home antibody tests put to the test: can you read your own COVID-19 result?
- Can lung ultrasound reveal COVID-19's signature in the lungs?
- When the immune system Can't fight back: tracking three respiratory viruses
- The household maze: how does COVID-19 move between family members?
- Can an oral drug stop COVID-19 from turning deadly?
- Can COVID-19 rapid tests slip into HIV and TB clinics without disrupting care?