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Athletes' own blood may speed knee healing after ACL surgery

NCT ID NCT07257666

Disease control Sponsor: University of Belgrade Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether applying platelet-rich fibrin (PRF), a gel made from the patient's own blood, to the knee after ACL reconstruction can reduce numbness and improve function. Fifty-three male athletes were split into two groups: one received PRF during surgery, the other standard closure. The main goal was to see if PRF reduced sensory loss at the donor site one year after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
platelet-rich fibrin (PRF)
What this could lead to
If it works, this could point toward a simple way to improve recovery and reduce numbness after ACL surgery.
What could go wrong
This is a small, early pilot study with only 53 participants, so results may not apply to everyone. PRF is made from the patient's own blood, so risks are low but benefits are still unproven.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

53 people

The number who actually took part.

Started

Jan 2022

Finished

Jul 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients undergoing ACL reconstruction with bone-patellar tendon-bone (BPTB) autograft at the University Clinical Center of Serbia

Ages

18 to 40 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-40 years * Isolated anterior cruciate ligament rupture confirmed by MRI and clinical examination * Planned ACL reconstruction with BPTB autograft * Written informed consent provided Exclusion Criteria: * Previous knee surgery on the affected knee * Associated ligament injuries requiring additional reconstruction * Significant cartilage damage (Outerbridge grade III-IV beyond donor site changes) * Systemic disease affecting wound healing (e.g., diabetes mellitus, autoimmune disease) * Active infection * Refusal or inability to provide informed consent

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Conditions

The condition(s) this trial relates to.

Anterior Cruciate Ligament Injuries Knee Injuries Sensation Disorders

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Anterior cruciate ligament injury Bone-patellar tendon-bone autograft Knee injuries Platelet-rich fibrin (PRF) Sensory disorders

Contacts and locations

Locations

  • University Clinical Center of Serbia (UKCS)

    Belgrade, 11000, Serbia

More trials for these conditions

Other studies related to the condition(s) this trial covers.