Liver failure treatment study halted early

NCT ID NCT03702920

Terminated Disease control Sponsor: Grifols Therapeutics LLC Source: ClinicalTrials.gov ↗

First seen Dec 16, 2025 · Last updated May 23, 2026 · Updated 20 times

Summary

This study tested a blood-cleaning procedure called plasma exchange (using albumin) in people with severe, sudden liver failure on top of chronic liver disease. The goal was to see if it could help more patients survive for 90 days compared to standard care alone. The study was stopped early and involved 275 adults at high risk of dying in the hospital.

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Contacts and locations

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Locations

ASST Grande Ospedale Metropolitano Niguarda

Milan, 20162, Italy
ASST Papa Giovanni XXIII

Bergamo, 24127, Italy
Aurora Health Care, Inc.

Milwaukee, Wisconsin, 53215, United States
Azienda Ospedaliera di Padova

Padova, 35128, Italy
Azienda Ospedaliero-Universitaria Policlinico Umberto I

Roma, 161, Italy
Cedars-Sinai Medical Center

Los Angeles, California, 90048, United States
Centre Hépato-Biliaire - Hôpital Universitaire Paul Brousse

Villejuif, 94804, France
Centro Hospitalar Lisboa Norte

Lisbon, 1649-028, Portugal
Centro Hospitalar do Porto

Porto, Portugal
Emory University

Atlanta, Georgia, 30322, United States
Hannover Medical School

Hanover, 30625, Germany
Hospital Clínic de Barcelona

Barcelona, 08036, Spain
Hospital General Gregorio Marañón

Madrid, 28007, Spain
Hospital Universitario Ramón y Cajal

Madrid, 28034, Spain
Hospital Universitario del Valle Hebron

Barcelona, 08035, Spain
Hôpital Beaujon

Clichy, 92110, France
King's College Hospital NHS Foundation Trust

London, SE5 9RS, United Kingdom
Klinikum der Universitaet Muenchen

München, 81377, Germany
Mayo Clinic Phoenix

Phoenix, Arizona, 85054, United States
Mayo Clinic Rochester

Rochester, New York, 55905, United States
McGuire VA Medical Center

Richmond, Virginia, 23249, United States
Medical University of Vienna

Vienna, A-1090, Austria
Milano Hospital Fondazione IRCCS Ca Granda Ospedale Maggiore Policlinico

Milan, 20122, Italy
Nottingham University Hospital

Nottingham, NG72UH, United Kingdom
Ohio State University Wexner Medical Center

Columbus, Ohio, 43210, United States
Rigshospitalet

Copenhagen, Denmark
Royal Free NHS Foundation Trust Hospital

London, NW3 2QG, United Kingdom
Rutgers-New Jersey Medical School

Newark, New Jersey, 07101, United States
Southern California Research Center

Coronado, California, 92118, United States
UZ Leuven - Campus Gasthuisberg

Leuven, 3000, Belgium
Universitaetsklinikum Leipzig

Leipzig, 4103, Germany
University of Alabama at Birmingham (UAB) Hospital

Birmingham, Alabama, 35294, United States
University of Kansas

Kansas City, Kansas, 66045, United States
University of New Mexico

Albuquerque, New Mexico, 87131, United States
University of Pennsylvania

Philadelphia, Pennsylvania, 19104, United States
University of Pittsburgh Medical Center

Pittsburgh, Pennsylvania, 15213, United States
University of Washington Medical Center

Seattle, Washington, 98195, United States
Universitätsklinikum Bonn

Bonn, 53105, Germany
Universitätsklinikum Frankfurt

Frankfurt, 60590, Germany
Université libre de Bruxelles

Brussels, 1070, Belgium

Conditions

Explore the condition pages connected to this study.

ACUTE-ON-CHRONIC LIVER FAILURE