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Placebo power: personalized suggestions may ease pain

NCT ID NCT04669093

First seen Dec 10, 2025 · Last updated Jun 23, 2026 · Updated 28 times

Summary

This study tests whether placebo suggestions work better when they match a person's natural motivational style—either focusing on promoting good feelings or preventing pain. Sixty healthy adults will receive a plain hand cream but be told it's a pain reliever, with suggestions tailored to their style. Researchers will measure pain ratings, expectations, and facial expressions to see if the match makes a difference.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Dartmouth College

    Hanover, New Hampshire, 03755, United States

    Contact Email: •••••@•••••

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Placebo cream (hand cream) with behavioral suggestions

What this could lead to

If it works, this could point toward more effective, personalized ways to use placebos for pain relief.

What could go wrong

This is a small, early-stage study in healthy volunteers, not patients. The results may not apply to real-world pain conditions.

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.