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Fake pills, real relief? placebo study aims to cut opioid use after hip surgery

NCT ID NCT07373210

Symptom relief Sponsor: University of California, San Francisco Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking placebo pills alongside standard opioid painkillers can reduce pain and opioid use in adolescents and young adults after hip surgery. 64 participants will either receive the placebo plus usual care or usual care alone. The goal is to see if the placebo effect can help manage pain and lower the need for opioids.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
open-label placebo pills
What this could lead to
If it works, this could offer a way to reduce opioid use after surgery by harnessing the placebo effect, even when patients know the pills are fake.
What could go wrong
This is a small, early-stage trial with only 64 participants, so results may not apply widely. The placebo effect is unpredictable and may not significantly reduce pain or opioid consumption.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 64 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2026

An estimate. Start dates often move.

Expected to finish

Mar 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

13 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 13 to 40 years old, and * Undergo primary Bernese Periacetabular osteotomy (PAO) for symptomatic developmental dysplasia of the hip (DDH), and * Opioid-naïve prior to operation, and * Capable of completing study procedures, including daily pain and medication diaries as well as weekly questionnaires. Exclusion Criteria: * Undergoing PAO revision or any concurrent major surgical procedure * History of opioid use, substance use disorders, or alcohol abuse * Those with cognitive or physical impairments that would interfere with providing their own consent and the completion of study-related tasks * Pregnant individuals or those planning to become pregnant during the study period

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Conditions

The condition(s) this trial relates to.

developmental dysplasia of the hip

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opiates Periacetabular osteotomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of California San Francisco

    RECRUITING

    San Francisco, California, 94158, United States

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