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PKU carriers' hidden response to common amino acid revealed

NCT ID NCT06119048

Knowledge-focused Sponsor: University of Guelph Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at how people who carry the gene for PKU (but don't have the disease) handle a substance called phenylalanine, found in many foods. 56 adults, both carriers and non-carriers, took a phenylalanine drink and had their thinking, mood, blood pressure, and body chemistry measured. The goal was to understand if carriers have different responses that could affect their health.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

56 people

The number who actually took part.

Started

Jun 2024

Finished

Oct 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Carrier or non-carrier of PKU * At least 18 Years of age * Comfortable fasting the morning of the study (no food or drink other than water) Exclusion Criteria: * Diagnosed with: PKU, severe neurodegenerative conditions affecting cognition (e.g. Alzheimer's, Parkinson's, dementia), melanoma, hypertension, liver disease and/or kidney disease * Diagnosed with hypertension or hypotension * Taking a monoamine oxidase inhibitor anti-depressant * Pregnant or breastfeeding * Orange/citrus allergy or intolerance * Body weight 150 kg or greater * History of fainting during blood sampling

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Conditions

The condition(s) this trial relates to.

autosomal recessive disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Autosomal recessive disorder (genetic carriers of PKU)

Contacts and locations

Locations

  • University of Guelph

    Guelph, Ontario, N1G 2W1, Canada