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New study aims to predict which blockages need stenting after a heart attack

NCT ID NCT06506448

Knowledge-focused Sponsor: University Hospital Southampton NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This study looks at 320 people who had a severe heart attack (STEMI) and have blockages in other arteries besides the one that caused the attack. Researchers will use CT scans and blood tests to see which blockages are likely to cause future problems. The goal is to find out if only high-risk blockages need stenting, while others can be treated with medication alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to a more personalized approach where only high-risk blockages are stented after a heart attack, reducing unnecessary procedures and risks.
What could go wrong
This is an observational study, not a treatment trial. It aims to gather data, not test a therapy, so it won't directly change care. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 320 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2025

Expected to finish

Jan 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients presenting with ST elevation myocardial infarction who are found to have significant stenoses in the non-infarct related artery(s) defined as coronary stenosis \>50% by visual estimation

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Ability to provide written informed consent (post PPCI) 2. Age 18 years to 85 years 3. Presentation of acute STEMI within 12 hours of symptom on-set 4. Culprit artery PPCI 5. Coronary stenosis of \> 50% diameter stenosis by visual estimation in NIRA with a minimum diameter of 2.5mm Exclusion Criteria: 1. Cardiogenic shock 2. Decompensated heart failure requiring intubation, inotropes, or intra-aortic balloon counter pulsation 3. Refractory ventricular arrhythmia 4. Previous coronary artery bypass surgery (CABG) 5. Stent thrombosis and in stent restenosis 6. An intention before inclusion into the study to revascularize a non-culprit lesion 7. Active malignancy or inflammatory disorders such as rheumatoid arthritis or inflammatory bowel disease 8. Severe valvular heart disease requiring surgery 9. Planned surgical revascularisation 10. Active participation in another study/trial 11. \< 12 months life expectancy 12. Contraindication to CTCA * Presence of internal defibrillator * Known allergy to iodinated contrast * Pregnancy * Contraindication to intravenous beta blockade * Contraindication to acute sublingual nitrate administration * Mechanical prosthetic heart valve * Advanced renal impairment (creatinine \>200) * Significant valve disease (sever aortic stenosis or regurgitation; severe mitral regurgitation) Angiographic exclusion criteria 1. NIRA stenosis of 50% or more in the left main stem or the ostia of both the left anterior descending and circumflex arteries 2. \< TIMI (thrombolysis in myocardial infarction) flow grade 3 in the NIRA, 3. Evidence of thrombus in the NIRA.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder Inflammation ST-elevation myocardial infarction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ST elevation myocardial infarction

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    3 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Royal Stoke University Hospital

    RECRUITING

    Stoke-on-Trent, Staffordshire, ST4 6QG, United Kingdom

  • University Hospital Southampton NHS Foundation Trust

    RECRUITING

    Southampton, Hampshire, SO16 6YD, United Kingdom

  • University Hospitals Dorset NHS Foundation Trust

    RECRUITING

    Bournemouth, Dorset, BH15 2JB, United Kingdom

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