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Can exercise counteract Cancer's muscle wasting?

NCT ID NCT07807306

Disease control Sponsor: Pharos University in Alexandria Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 08, 2026 · Last updated Sep 09, 2026 · Updated 1 time

Summary

This trial tests whether a structured physical therapy program can help people with cancer-induced cachexia, a condition that causes severe muscle loss and weakness. Adults aged 40 to 60 who are receiving chemotherapy for non-metastatic cancer will either get standard care or add a 3-month program of aerobic and resistance exercises. Researchers will measure changes in blood markers linked to muscle and bone health, along with muscle strength and bone density, to see if exercise can ease cachexia and improve recovery before surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
A structured physical therapy program combining aerobic treadmill walking and resistance exercises, added to standard chemotherapy and nutritional support.
What this could lead to
If effective, this exercise program could offer a way to slow muscle wasting and improve strength and quality of life in people with cancer cachexia before surgery.
What could go wrong
The trial is small and early, so results may not apply broadly. Exercise may be hard to complete during chemotherapy, and benefits might not show up in the chosen biomarkers.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18 years or older. Confirmed diagnosis of non-metastatic cancer (Grade 2 or Grade 3). Diagnosed with Cancer-Induced Cachexia (CIC) based on international consensus criteria (weight loss \>5% in past 6 months, OR weight loss \>2% in individuals with BMI \<20 kg/m², OR appendicular skeletal muscle index consistent with sarcopenia). Scheduled for or currently receiving standard neoadjuvant chemotherapy. Ability to provide written informed consent and follow a structured physical therapy program. ECOG Performance Status of 0 to 2. Exclusion Criteria: * Evidence of distant tumor metastasis (Grade 4 cancer). Severe orthopedic, neurological, or cardiovascular conditions preventing participation in safe physical therapy exercise. Uncontrolled cardiovascular disease (e.g., unstable angina, recent myocardial infarction, severe cardiac arrhythmias). Severe bone metastases or pathologic fracture risk that contraindicates weight-bearing exercises. Prior participation in regular structured aerobic or resistance exercise training within the past 6 months. Cognitive impairment or psychiatric conditions interfering with treatment compliance or informed consent.

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Conditions

The condition(s) this trial relates to.

neoplasm Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cancer cachexia Sarcopenia

How to take part

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  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

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