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Sitting less, moving more: new study reveals Body-Wide effects of activity changes

NCT ID NCT06377254

Knowledge-focused Sponsor: University of Nottingham Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at how increasing or decreasing physical activity changes the way your body works. Forty overweight adults aged 50-65 will either become less active for 3 months then retrain, or become more active for 6 months. Researchers will measure fitness, muscle strength, brain function, and take tissue samples to understand the full-body impact.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could reveal how physical activity and inactivity impact multiple body systems, helping shape better public health advice for healthy aging.
What could go wrong
This is an early-stage observational intervention with only 40 participants. Results may not apply to everyone, and the study does not test a treatment or cure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Mar 2024

Expected to finish

Oct 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

50 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Group 1 ('non-sedentary') self-reporting \<6 sedentary hrs/day, not actively involved in exercise training or a regular physical activity regimen (\>8,000 steps/day). * Group 2 ('sedentary') self-reporting ≥8 waking hrs/day in sedentary activities and/or ≤5,000 steps/day. * Aged 50-65y. * Overweight (BMI 25-35 kg/m2). * Waist circumference ≥94cm (males) and ≥80cm (females). * Willing to alter physical activity levels as instructed for 6 months * Without neurological or psychiatric diseases, motor or cognitive restrictions * Ability to give informed consent Exclusion Criteria: * Regular medication use that could interfere with measures * A history, or evidence, of chronic cardiovascular, metabolic, musculoskeletal, renal or respiratory diseases. * Experiencing 'long-COVID', inflammatory bowel disease or malignancy. * Uncontrolled hypertension. Stage 1 hypertension (BP ≤160/100mmHg) with no other signs of cardiovascular disease, and blood pressure (BP) managed by routine medication will not be an exclusion. * People employed in jobs that would preclude reducing step count and night-shift workers. * Females who are pre/peri-menopausal, (due to effect of oestrogen fluctuations on primary outcomes and the longitudinal study design), but individuals stable on hormone replacement therapy are eligible. * Contraindications for MRI. * Allergy or sensitivity to local anaesthesia, or dressing adhesive

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Conditions

The condition(s) this trial relates to.

abdominal obesity-metabolic syndrome metabolic syndrome X Motor Activity Overweight Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Age-related cognitive decline Age-related sarcopenia Metabolic syndrome Sedentary behavior

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • David Greenfield Human Physiology Unit

    RECRUITING

    Nottingham, Notts, NG72UH, United Kingdom

More trials for these conditions

Other studies related to the condition(s) this trial covers.