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Light and vitamin d: a new hope for gum disease?

NCT ID NCT06700122

Disease control Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tested whether adding photodynamic therapy (a light-based treatment) and vitamin D to standard deep cleaning helps people with moderate gum disease. Twenty-four adults with stage II grade B periodontitis took part. The goal was to see if the combination improves gum attachment and reduces pocket depth better than cleaning alone.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Photodynamic therapy and vitamin D
What this could lead to
If successful, this combination could improve gum health and reduce the need for more invasive procedures in people with periodontitis.
What could go wrong
This is a small, completed trial with only 24 participants. Results may not apply to everyone, and the benefits over standard care alone are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

24 people

The number who actually took part.

Started

Mar 2025

Finished

May 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 50 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Systemic healthy patients * Patients aged \> 25 years * Patients suffering from stage II periodontitis with grade B were included in this study, according to 2017 world workshop classification of periodontal disease. * Patients with interdental clinical attachment loss (CAL) of 3-4 mm with radiographic evidence of bone loss extending to coronal third of the root. * Radiographic bone loss (RBL) will be diagnosed using periapical parallel technique using 6 radiographic images for full mouth (3- radiographic images for maxillary arch and 3- radiographic images for mandibular arch) including anterior, canine region and posterior teeth at baseline for diagnosis. * No history of previous periodontal therapy. * No taken medications known to interfere healing or periodontal tissue health such as anticonvulsants, calcium channel blockers, or immunosuppressant drugs. * No previous periodontal surgery at involved sites. * Good oral hygiene and good compliance with the plaque control instructions following initial therapy. * Neither taken antibiotics within the last three months nor nonsteroidal anti-inflammatory drugs within the last three months * Absence of diseases or conditions that would interfere with wound healing such as diabetes mellitus or coagulation disorders Exclusion Criteria: Patients taking Vitamin D as a nutritional supplement were excluded from the study * Smoking habits * Pregnant and lactating mothers * Patients who have been received periodontal surgery in the study area during the last 6 months.

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Conditions

The condition(s) this trial relates to.

periodontitis vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Vitamin D deficiency

Contacts and locations

Locations

  • Marwa Helal

    Cairo, 02, Egypt

More trials for these conditions

Other studies related to the condition(s) this trial covers.