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New light therapy could save failing dental implants

NCT ID NCT07191522

Disease control Sponsor: Egas Moniz - Cooperativa de Ensino Superior, CRL Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding a light-activated treatment (photodynamic therapy) to standard deep cleaning helps fight infections around dental implants better than cleaning alone. Forty adults with peri-implantitis will receive one of the two treatments, and researchers will measure gum pocket depth, bleeding, and bone loss after 6 weeks. The goal is to find a more effective non-surgical way to preserve implants and prevent implant loss.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
antimicrobial photodynamic therapy (aPDT) using a light-sensitive compound and specific light
What this could lead to
If it works, this could offer a better non-surgical option to treat gum infections around dental implants, potentially saving more implants from being lost.
What could go wrong
This is a small, early-stage trial with only 40 participants and a short 6-week follow-up. The added benefit of photodynamic therapy may be small or not last long, and results may not apply to smokers or people with other health conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2025

Expected to finish

Jul 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * patients over 18 years of age; * patients with one or more implants diagnosed with peri-implantitis rehabilitated for at least one year; * PI and GI \< 25%. Exclusion Criteria: * smoking patients; * patients with uncontrolled periodontitis; * systemic diseases that influence the study (diabetes); * inadequate prosthetic rehabilitation that cannot be modified or that prevents access for physical decontamination; * implants rehabilitated with cemented crowns; * pregnant and lactating women; * previous surgical intervention at the same site; * therapy with non-steroidal anti-inflammatory drugs (NSAIDs), antibiotics or immunosuppressants in the last 3 months; * patients previously undergoing chemotherapy or radiotherapy; * PI and IG \> 25%; * uncooperative patients.

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri-implantitis

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Egas Moniz School of Health and Science

    RECRUITING

    Almada, Monte Da Caparica, 2829-511, Portugal

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