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Which drug is safer for baby during C-Section? new study compares phenylephrine and ephedrine

NCT ID NCT06741410

Knowledge-focused Sponsor: Centre of Postgraduate Medical Education Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 1 time

Summary

This completed study looked at 94 women who had a planned C-section under spinal anesthesia. Doctors compared two drugs used to prevent low blood pressure: a continuous drip of phenylephrine versus bolus injections of ephedrine. The main goal was to see which approach led to healthier umbilical blood pH in newborns, a sign of how well the baby tolerated the procedure.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Phenylephrine and ephedrine
What this could lead to
If it works, this could help doctors choose the safer drug to maintain newborn health during cesarean delivery.
What could go wrong
This is a small, retrospective study, so results may not apply to all patients. It only looks at one measure of newborn well-being.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

94 people

The number who actually took part.

Started

Dec 2024

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Initial cohort of patients will consist of selected cases of cesarean deliveries from Orlowski Hospital in years 2020 - 2022, Department of Obstetrics and Gynaecology, Warsaw, Poland. Intention is to include 40 cases in each group.

Ages

18 years and older

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Cesarean delivery at term under spinal anesthesia * American Society of Anesthesiologists (ASA) physical status \<3 * BMI \<40 * Preemptive phenylephrine infusion or ephedrine boluses used during surgical procedure Exclusion Criteria: * No vasoconstrictor (phenylephrine nor ephedrine) used throughout the procedure * Total dose of ephedrine less than 15mg * poor quality of anesthetic record - data required for analysis not available

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Conditions

The condition(s) this trial relates to.

acidosis disorder hypotensive disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cesarean delivery Neonatal acidosis Spinal anesthesia

Contacts and locations

Locations

  • Centre of Postgraduate Medical Education,Department of Anesthesia and Intensive Care

    Warsaw, 01-813, Poland

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