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New brain zapping method tested in humans for first time

NCT ID NCT07179848

Knowledge-focused Sponsor: Taipei Veterans General Hospital, Taiwan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial is testing whether a new non-invasive brain stimulation technique called temporal interference stimulation (TIBS) is safe in healthy adults aged 20 to 65. Participants will receive either real or sham stimulation to different brain regions over 10 days, with cognitive tests and MRI scans before and after. The goal is to check for side effects and brain changes, not to treat any disease.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Temporal interference brain stimulation (TIBS) device
What this could lead to
If successful, this could pave the way for a safer, non-invasive way to stimulate deep brain areas, potentially helping treat conditions like depression or chronic pain without surgery.
What could go wrong
This is a very early Phase 1 safety trial in healthy volunteers, not patients. It is small (80 people) and only tests short-term effects, so it may not translate to real-world treatments or show any benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 1

The first testing in people. Mainly checks safety and dose, usually in a small group.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Feb 2025

Expected to finish

Oct 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Healthy adults from the community * Age between 20 and 65 years old * No diagnosis of severe psychiatric disorders * No family history of psychiatric diseases Exclusion Criteria: * Age below 20 years old or above 65 years old * Currently prescribed any medication * Diagnosis of psychiatric disorders (e.g., Major Depressive Disorder, Bipolar Disorder, Schizophrenia) * Diagnosis of neurological disorders (e.g., Dementia, Stroke, Parkinson's disease) * History of substance abuse * Diagnosis of cancer or malignant tumors * Chronic kidney failure or undergoing hemodialysis * Pregnant or breastfeeding * Severe arrythmia, presence of pacemaker, or metal implants in the brain * Claustrophobia * History or family history of seizure * History of syncope * Organic brian disease, brian trauma, or history of neurosurgery * Received electroconvulsive therapy or repetitive transcranial magnetic stimulation within the past month * Skin disorders (e.g., dermatitis, psoriasis, eczema) * Currently participating in other clinical interventional trials * Presence of any metal implants or devices affected by electromagnetic fields

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Crossover study Health adults Safety and effectiveness Temporal interference stimulation

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 112, Taiwan

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