ICU patients may get fewer unnecessary acid pills thanks to pharmacist checks
NCT ID NCT06225167
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a pharmacist-driven protocol to stop stomach ulcer prevention drugs in ICU patients when they are no longer needed. The goal was to reduce unnecessary medication and side effects without increasing the risk of stomach bleeding. The trial included 120 adult ICU patients and compared those who continued the drugs with those who stopped under the protocol.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- pharmacist-driven protocol to discontinue stress ulcer prophylaxis
- What this could lead to
- If successful, this approach could reduce unnecessary use of acid-suppressing drugs in ICUs, lowering costs and side effects like infections.
- What could go wrong
- This is a small, single-center study (120 patients) focused on protocol feasibility, not a large trial. Results may not apply to all ICUs, and there is a small risk of gastrointestinal bleeding if medication is stopped too early.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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120 people
The number who actually took part.
- Started
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May 2023
- Finished
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Jul 2023
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Patients ≥18 years ICU location status stress ulcer prophylaxis in ICU patients when it is no longer indicated according to pre-defined criteria.
- Ages
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18 to 85 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Patients ≥18 years ICU location status Exclusion Criteria: * If patient has one of the following: * Coagulopathy (defined as: platelets \< 50,000/µL, international normalized ratio(INR) \> 1.5, or partial thromboplastin time \> 2 times the control value) * Mechanical ventilation for \> 48 hours and on \< 50% goal tube feeds * Shock state on vasopressors/inotropes and on \< 50% goal tube feeds (or \< 50% of diet) * On total parenteral nutrition * Use of acid suppressive therapy prior to admission * Admission with GI bleeding * History of peptic ulcer disease * Surgery on the GI tract or cardiac surgery during the current hospital admission * Pregnancy * H. pylori infection treatment * Hypersecretory disorder (ex: Zollinger-Ellison) * Known erosive esophagitis/gastritis (not heartburn or gastroesophageal reflux disease) * Traumatic brain injury with Glasgow Coma Scale score ≤ 10 * Major burn (˃30% body surface area) * Major trauma requiring ICU admission * Spinal cord injury requiring ICU admission If patient has two or more of the following: * Administration of ˃ 100 mg daily of prednisolone (or equivalent) * Sepsis * Acute renal failure * Acute hepatic failure
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Methodist Richardson Medical Center
Richardson, Texas, 75082, United States