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New pfizer combo aims to outperform current therapy for stomach cancer

NCT ID NCT07392892

Disease control Sponsor: Pfizer Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Aug 18, 2026 · Updated 5 times

Summary

This study tests a new experimental drug, PF-08634404, combined with chemotherapy in people with advanced stomach, gastroesophageal junction, or esophageal cancer that has not been treated before. The trial has two parts: first checking safety and response, then comparing the new combo to an approved treatment (nivolumab plus chemo). About 840 participants will take part to see which approach works better at shrinking tumors and extending life.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
PF-08634404 (also known as SSGJ-707) given intravenously with chemotherapy
What this could lead to
If it works, this could offer a new first-line treatment option for people with advanced stomach or esophageal cancer, potentially improving how long they live or delaying cancer growth.
What could go wrong
This is an early-to-mid stage trial (Phase 2/3), so the drug may not prove better than the existing treatment (nivolumab plus chemo). Side effects from the combination are unknown and could be serious.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 840 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jul 2032

An estimate. End dates often move.

Lead sponsor

A company

The lead sponsor is a pharmaceutical, biotech, or medical-device company.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Histological or cytological confirmed gastric, gastroesophageal junction or esophageal adenocarcinoma. * Evidence of locally advanced or metastatic disease. * Eastern Cooperative Oncology Group performance status (ECOG) 0-1 * No prior systemic therapy for advanced or metastatic disease. * Adequate hepatic, liver, and renal function * HER-2 negative status based on local testing * PD-L1 positive status based on local testing Exclusion Criteria: * Participants with known active CNS metastases, including leptomeningeal, brainstem, meningeal, or spinal cord metastases or compression * Clinically significant risk of hemorrhage or fistula * Major surgery or severe trauma within 4 weeks prior to the first dose, or planned major surgery during the study * History of allogeneic organ transplantation and allogeneic hematopoietic stem cell transplantation. * Any Grade ≥3 bleeding/hemorrhage events within 28 days of Cycle 1 Day 1, or prior history of clinically significant bleeding events * Clinically significant cardiovascular disease, or other comorbidities, within 6 months prior to first dose * Participants with active autoimmune diseases requiring systemic treatment within the past 2 years * Evidence of non-infectious or drug-induced interstitial lung disease (ILD) pneumonitis

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Get notified about this study

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Conditions

The condition(s) this trial relates to.

Adenocarcinoma Of Esophagus esophageal adenocarcinoma gastric adenocarcinoma gastric cancer gastric neoplasm gastroesophageal cancer gastroesophageal junction adenocarcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Esophageal adenocarcinoma Gastroesophageal junction cancer Metastatic gastric cancer Untreated advanced or metastatic gastric, gastroesophageal junction, or esophageal adenocarcinoma

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    74 sites in 8 countries. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Aichi Cancer Center

    RECRUITING

    Nagoya, Aichi-ken, 464-8681, Japan

  • Alliance Cancer Specialists, PC

    RECRUITING

    Bensalem, Pennsylvania, 19020, United States

  • Alliance Cancer Specialists, PC

    RECRUITING

    Doylestown, Pennsylvania, 18901, United States

  • Alliance Cancer Specialists, PC

    RECRUITING

    Horsham, Pennsylvania, 19044, United States

  • Alliance Cancer Specialists, PC

    RECRUITING

    Langhorne, Pennsylvania, 19047, United States

  • Alliance Cancer Specialists, PC

    RECRUITING

    Media, Pennsylvania, 19063, United States

  • Alliance Cancer Specialists, PC

    RECRUITING

    Sellersville, Pennsylvania, 18960, United States

  • Alliance Cancer Specialists, PC

    RECRUITING

    Wynnewood, Pennsylvania, 19096, United States

  • Atlantic Health System

    NOT_YET_RECRUITING

    Morristown, New Jersey, 07960, United States

  • Atlantic Health System / Overlook Medical Center

    NOT_YET_RECRUITING

    Summit, New Jersey, 07901, United States

  • Fred Hutchinson Cancer Center

    RECRUITING

    Seattle, Washington, 98109, United States

  • Harborview Medical Center

    RECRUITING

    Seattle, Washington, 98104, United States

  • Hospital Universitari Vall d'Hebron

    NOT_YET_RECRUITING

    Barcelona, Barcelona [barcelona], 08035, Spain

  • Illinois Cancer Specialists

    RECRUITING

    Arlington Heights, Illinois, 60005, United States

  • Illinois Cancer Specialists

    RECRUITING

    Chicago, Illinois, 60631, United States

  • Illinois Cancer Specialists

    RECRUITING

    Niles, Illinois, 60714, United States

  • Illinois CancerCare - Bloomington

    RECRUITING

    Bloomington, Illinois, 61704, United States

  • Illinois CancerCare - Galesburg

    RECRUITING

    Galesburg, Illinois, 61401, United States

  • Illinois CancerCare, P.C.

    RECRUITING

    Peoria, Illinois, 61615, United States

  • Illinois CancerCare-Ottawa-Fox River Cancer Center

    RECRUITING

    Ottawa, Illinois, 61350, United States

  • Illinois CancerCare-Pekin

    RECRUITING

    Pekin, Illinois, 61554, United States

  • Illinois CancerCare-Peru - Valley Regional Cancer Center

    RECRUITING

    Peru, Illinois, 61354, United States

  • Illinois CancerCare-Washington

    RECRUITING

    Washington, Illinois, 61571, United States

  • Istituto Europeo di Oncologia IRCCS

    NOT_YET_RECRUITING

    Milan, 20141, Italy

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Annapolis, Maryland, 21401, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Bethesda, Maryland, 20817, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Brandywine, Maryland, 20613, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Columbia, Maryland, 21044, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Germantown, Maryland, 20876, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Largo, Maryland, 20774, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Rockville, Maryland, 20850, United States

  • Maryland Oncology Hematology, P.A.

    RECRUITING

    Silver Spring, Maryland, 20904, United States

  • National Cheng Kung University Hospital

    NOT_YET_RECRUITING

    Tainan, 704302, Taiwan

  • National Taiwan University Hospital

    RECRUITING

    Taipei, 10002, Taiwan

  • Oncology Hematology Care Clinical Trials, LLC

    RECRUITING

    Cincinnati, Ohio, 45211, United States

  • Oncology Hematology Care Clinical Trials, LLC

    RECRUITING

    Cincinnati, Ohio, 45242, United States

  • Oncology Hematology Care Clinical Trials, LLC

    RECRUITING

    Cincinnati, Ohio, 45245, United States

  • Oncology Hematology Care Clinical Trials, LLC

    RECRUITING

    Fairfield, Ohio, 45014, United States

  • Pan American Center for Oncology Trials, LLC - Bayamón Office

    RECRUITING

    Bayamón, 00959, Puerto Rico

  • Pan American Center for Oncology Trials, LLC - Manati Office

    RECRUITING

    Manati, United States, 00674, Puerto Rico

  • Rabin Medical Center

    RECRUITING

    Petah Tikva, Central District, 4941492, Israel

  • Renown Health Medical Oncology

    RECRUITING

    Reno, Nevada, 89502, United States

  • Renown Office of Clinical Research

    RECRUITING

    Reno, Nevada, 89502, United States

  • Renown Regional Medical Center

    RECRUITING

    Reno, Nevada, 89502, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Aurora, Colorado, 80012, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Boulder, Colorado, 80303, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Centennial, Colorado, 80112, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Colorado Springs, Colorado, 80907, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Colorado Springs, Colorado, 80923, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Denver, Colorado, 80218, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Denver, Colorado, 80220, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Englewood, Colorado, 80113, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Lakewood, Colorado, 80228, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Littleton, Colorado, 80120, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Lone Tree, Colorado, 80124, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Longmont, Colorado, 80504, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Pueblo, Colorado, 81003, United States

  • Rocky Mountain Cancer Centers, LLP

    RECRUITING

    Thornton, Colorado, 80260, United States

  • Sheba Medical Center

    RECRUITING

    Ramat Gan, HA Merkaz, 5265601, Israel

  • Sourasky Medical Center

    RECRUITING

    Tel Aviv, TELL ABĪB, 6423906, Israel

  • Taipei Veterans General Hospital

    RECRUITING

    Taipei, 11217, Taiwan

  • US Oncology Investigational Products Center (IPC)

    RECRUITING

    Irving, Texas, 75063, United States

  • University of Washington Medical Center

    RECRUITING

    Seattle, Washington, 98195, United States

  • Virginia Cancer Specialists, PC

    RECRUITING

    Arlington, Virginia, 22201, United States

  • Virginia Cancer Specialists, PC

    RECRUITING

    Fairfax, Virginia, 22031, United States

  • Virginia Cancer Specialists, PC

    RECRUITING

    Manassas, Virginia, 20110, United States

  • Virginia Cancer Specialists, PC

    RECRUITING

    Reston, Virginia, 20190, United States

  • Virginia Cancer Specialists, PC

    RECRUITING

    Woodbridge, Virginia, 22191, United States

  • Virginia Oncology Associates

    RECRUITING

    Chesapeake, Virginia, 23320, United States

  • Virginia Oncology Associates

    RECRUITING

    Hampton, Virginia, 23666, United States

  • Virginia Oncology Associates

    RECRUITING

    Newport News, Virginia, 23606, United States

  • Virginia Oncology Associates

    RECRUITING

    Norfolk, Virginia, 23502, United States

  • Virginia Oncology Associates

    RECRUITING

    Virginia Beach, Virginia, 23456, United States

  • Zhongshan Hospital,Fudan University

    RECRUITING

    Shanghai, Shanghai Municipality, 200031, China

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