New PET probe aims to spot lung scarring earlier
NCT ID NCT07459179
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times
Summary
This study tests a special PET probe that targets a protein called DDR2, which is linked to lung scarring in interstitial lung disease. Researchers will scan 50 patients to see if the probe can accurately detect the disease and also check for related cognitive problems. The goal is to improve early diagnosis and guide treatment.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- PET probe targeting DDR2
- What this could lead to
- If successful, this could enable earlier and more accurate diagnosis of interstitial lung disease, potentially improving treatment timing and outcomes.
- What could go wrong
- This is an early-stage diagnostic study with only 50 participants, so results may not apply broadly. The probe's effectiveness and safety are still unproven.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 50 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Apr 2026
An estimate. Start dates often move.
- Expected to finish
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Dec 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
patients with interstitial lung disease (ILD) or interstitial lung disease complicated by cognitive impairment
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * No gender restriction, age ≥18 years (inclusive); * Patients with interstitial lung disease who meet one of the following diagnoses: connective tissue disease-associated interstitial lung disease (CTD-ILD), idiopathic nonspecific interstitial pneumonia (iNSIP), chronic allergic pneumonia, sarcoidosis, environmental/occupational lung disease, or unclassifiable idiopathic interstitial disease (IIP); * Screening subjects who were definitively diagnosed with interstitial lung disease (ILD) by high-resolution computed tomography (HRCT) within the preceding 6 months; * In the first 3 months prior to screening, the carbon monoxide diffusion capacity (DLCO) (Hb-corrected) was within 30% to 80% (inclusive) of the predicted value; the forced vital capacity (FVC) was within 40% to 70% (inclusive) of the predicted value; * The chief complaint is memory decline or other symptoms of cognitive impairment, with a disease course of ≥3 months; * meets the diagnostic criteria for cognitive impairment caused by Alzheimer's disease (AD), mild cognitive impairment (MCI), or other related neurodegenerative diseases; * The scores on the cognitive function screening scale meet the criteria for cognitive impairment (e.g., Mini-Mental State Examination (MMSE) \<24 points, or Montreal Cognitive Assessment (MoCA) \<26 points); * Exclusion of cognitive dysfunction caused by severe depression, brain trauma, brain tumors, cerebrovascular accidents, etc. Exclusion Criteria: * patients in critical condition requiring emergency care; * Individuals with drug and/or alcohol abuse, or those with allergic predisposition; * women of childbearing potential, pregnant and lactating women; * bacterial, viral or fungal infections that require systemic treatment; * The study excluded participants deemed unsuitable by the investigators.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Daping Hospital, Army Medical University
Chongqing, Chongqing Municipality, 400010, China
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