New scan could spot breast cancer receptors without needle biopsy
NCT ID NCT03212170
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether a special PET/MRI scan using a tracer called FFNP can accurately measure progesterone receptors in invasive breast cancer. Twenty-one women with breast tumors at least 1 cm in size took part. The goal was to see if the scan results match the standard lab test done on biopsy tissue, which could lead to a less invasive way to assess hormone receptor status.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 2
Tests whether the treatment actually works, and watches for side effects, in a larger group.
- Participants
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21 people
The number who actually took part.
- Started
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Dec 2017
- Finished
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Nov 2024
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
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Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women 18 years of age or older * Diagnosis of biopsy-proven invasive breast cancer measuring at least 1.0 cm in diameter by any imaging modality * Biopsy-proven PR-positive or PR-negative invasive breast cancer * Undergoing diagnostic breast MRI ordered by the referring clinician for staging and extent of disease Exclusion Criteria: * Inability or unwillingness to provide informed consent to the study * Participants currently undergoing neoadjuvant chemotherapy/endocrine therapy or those who have received chemotherapy/endocrine therapy within 6 months prior to the MRI * Participants who have had neoadjuvant chemotherapy/endocrine therapy, surgical intervention, or radiation for the current biopsy-proven malignancy * Participants with breast expanders * Participants who are or might be pregnant or lactating * Participants with a contraindication to gadolinium based contrast agents, including allergy or impaired renal function (per University of Wisconsin Health Guidelines) * Participants with a history of allergic reaction attributable to compounds of similar chemical or biologic composition to FFNP * Participants in liver failure as judged by the patient's physician * Participants with standard contraindications to MRI, including claustrophobia and metallic implants incompatible with MRI * Participants requiring intravenous (IV) conscious sedation for imaging are not eligible; participants requiring mild, oral anxiolytics for the clinical MRI will be allowed to participate as long as the following criteria are met: * The subject has their own prescription for the medication * The informed consent process is conducted prior to the self-administration of this medication * They come to the research visit with a driver * Participants unable to lie prone for 30 minutes for imaging
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Wisconsin, Madison
Madison, Wisconsin, 53705, United States
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Other studies related to the condition(s) this trial covers.
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