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Tailored therapy may ease persistent concussion symptoms

NCT ID NCT06069700

Symptom relief Sponsor: University Health Network, Toronto Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether personalized rehabilitation treatments help adults with persistent concussion symptoms better than usual care. 40 participants received either individualized therapy (aerobic exercise, mindfulness, or physical therapy) or standard care for 6 weeks, then switched. The goal was to see if tailored treatment improves recovery and brain function.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
individualized rehabilitative therapy (aerobic exercise, mindfulness, or physical therapy)
What this could lead to
If it works, this could point toward a more effective, tailored approach for treating persistent concussion symptoms.
What could go wrong
This is a small, early-stage study with only 40 participants, so results may not apply to everyone. The treatments are non-drug and effects may be modest.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Jan 2023

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 21-years and older * meet the definition of postconcussion syndrome, which requires a participant to report any 3 symptoms or more (from an inclusive list of 40 most commonly reported persisting symptoms) lasting at least 1-month following the diagnosis of a concussion. Concussion was defined according to the 5th International Consensus Statement on Concussion in Sport. * Have adequate language skills in English to read and take part in rehabilitation treatment program. Exclusion Criteria: * In-patients at Toronto Rehabilitation Institute or any other affiliated University Health Network clinics. * Participants will be excluded should their clinical examination be unremarkable for objective physical impairments, * Have a chronic infectious disease, * Uncontrolled hypertension, * Other neurological disorders (not attributed to their primary diagnosis), * Cancer treatment (other than basal cell carcinoma), craniotomy, or refractory subdural hematoma long-term use of psychoactive medications that would compromise their ability to comprehend and perform study activities, those with pacemakers or elevated cardiovascular risk, * Ongoing litigation surrounding their injury, * Have been diagnosed with a moderate or severe brain injury prior to enrolment, post-concussive symptoms persisting beyond 12-months.

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Conditions

The condition(s) this trial relates to.

Brain Concussion Post-Concussion Syndrome traumatic brain injury

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mild traumatic brain injury Postconcussion syndrome

Contacts and locations

Locations

  • Toronto Rehabilitation Institute

    Toronto, Ontario, M5G 2A2, Canada

More trials for these conditions

Other studies related to the condition(s) this trial covers.