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Custom brain exercises show promise for schizophrenia thinking skills

NCT ID NCT04554121

Symptom relief Sponsor: Columbia University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether personalizing cognitive training based on a person's early auditory processing ability improves thinking and daily function in schizophrenia. 194 adults with schizophrenia or schizoaffective disorder were assigned to either a tailored program (Brain Basics) or standard cognitive training (Brain Training). The goal was to see if matching the exercises to each person's auditory strengths and weaknesses leads to better outcomes in verbal learning and functional capacity.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cognitive remediation therapy (computer-based brain exercises plus group discussions)
What this could lead to
If successful, this approach could lead to more effective cognitive training for people with schizophrenia, improving memory and daily living skills.
What could go wrong
This is a completed study, but the intervention is behavioral and effects may be modest. Results may not apply to all patients or settings.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

194 people

The number who actually took part.

Started

Dec 2020

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 68 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * A primary DSM-5 diagnosis of schizophrenia or schizoaffective disorder * Psychiatrically stable, as defined by no changes in psychotropic medication or psychiatric hospitalization in the most recent 21 days * English-speaking Exclusion Criteria: * Indications of Intellectual Disability as documented in medical history or measured by \< 70 premorbid Full Scale IQ * Documented auditory disorder or known visual impairment; presence of neurological conditions that are impacting brain and cognitive functioning * Unremitted substance dependence within the past six months * Participation in cognitive remediation in the 24 months prior

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Conditions

The condition(s) this trial relates to.

Psychotic Disorders schizoaffective disorder schizophrenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Schizoaffective disorder Schizophrenia

Contacts and locations

Locations

  • Heights Hill Clinic

    Brooklyn, New York, 11217, United States

  • Institute for Community Living

    Brooklyn, New York, 11207, United States

  • Laurel House

    Stamford, Connecticut, 06902, United States

  • Manhattan Psychiatric Center 125th Street Clinic

    New York, New York, 10027, United States

  • Mapleton Mental Health Services

    Brooklyn, New York, 11230, United States

  • Pibly Residential Programs Inc.

    The Bronx, New York, 10461, United States

  • Rockland Psychiatric Center

    Orangeburg, New York, 10962, United States

  • The Bridge, Inc.

    New York, New York, 10025, United States

  • Williamsburg Clinic

    Brooklyn, New York, 11206, United States

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