Knee replacement showdown: which implant works best?
NCT ID NCT03073941
First seen Jun 02, 2026
Summary
This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to better outcomes.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Copenhagen University hospital, Gentofte
Copenhagen, DK-2900, Denmark
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Dept. of Orthopaedic Surgery, Farsø Sygehus, Ålborg Universitetshospital
Aalborg, DK-9000, Denmark
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Dept. of Orthopaedic Surgery, Næstved Sygehus
Næstved, DK-4700, Denmark
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Dept. of Orthopaedic Surgery, Vejle Sygehus, Sygehus Lillebælt
Vejle, DK-7100,, Denmark
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Hvidovre hospital
Copenhagen, Denmark
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Persona total knee system (device) and NexGen total knee system (device)
What this could lead to
If one system proves better, it could lead to improved knee function and less pain after replacement surgery.
What could go wrong
This is a device comparison study, not a new treatment. Results may show no meaningful difference, and individual outcomes vary.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.