New combo may stop opioids from making pain worse
NCT ID NCT01594047
First seen Nov 01, 2025 · Last updated Jun 18, 2026 · Updated 24 times
Summary
This study tested whether giving ketamine during surgery and methadone after surgery can prevent the extra pain sensitivity that opioids sometimes cause. 113 adults having open colorectal surgery took part. The goal was to see if these drugs reduce the area of increased pain around the surgical wound and lower overall pain and opioid use.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Locations
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Fondazione IRCCS Istituto Nazionale dei Tumori
Milan, 20133, Italy
Conditions
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