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Vitamin d levels in gum fluid may predict implant trouble

NCT ID NCT07280754

Knowledge-focused Sponsor: Recep Tayyip Erdogan University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study will measure vitamin D and a natural antimicrobial peptide called LL-37 in the fluid around dental implants. Researchers want to see if these levels can help detect early signs of peri-implantitis or mucositis. The study includes 72 adults aged 18-65 who have had implant-supported prostheses for at least one year. If successful, it could lead to earlier diagnosis and better management of these common implant complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could lead to earlier diagnosis of peri-implant diseases, potentially reducing treatment costs and improving outcomes.
What could go wrong
This is an observational study with only 72 participants, so results may not apply broadly. It measures biomarkers, not treatments, so direct patient benefit is not guaranteed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 72 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Dec 2025

An estimate. Start dates often move.

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The G\*Power analysis performed to determine the number of samples to be included in the study determined that a total of 72 samples/implants should be included, with a minimum of 24 in each group, when the power of the test was taken as 0.85, the effect size as 0.4, and the Type-1 error (α) as 0.05.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Being between the ages of 18-65, * Having dental implants and using implant-supported prostheses for at least one year, * Not having used systemic and/or topical antibiotics/anti-inflammatory drugs or mouthwashes in the last three months, * Not having received periodontal/peri-implant treatment in the last six months. Exclusion Criteria: * Having a systemic disease or condition that affects peri-implant status, * Having a metabolic bone disease, * Bruxism, * Being pregnant or lactating, * Having received periodontal/peri-implant treatment within the last 6 months, * Smoking and alcohol use, * Taking vitamin D supplements.

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Conditions

The condition(s) this trial relates to.

Peri-Implantitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Peri implant mucositis Peri-implantitis

How to take part

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  1. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

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