Can peppermint oil help stop heart disease before it starts?
NCT ID NCT07815899
First seen Sep 11, 2026 · Last updated Sep 11, 2026
Summary
Researchers are testing whether peppermint oil supplements can improve heart health markers in adults with pre-metabolic syndrome, a condition where people have some risk factors for heart disease and diabetes but do not meet the full criteria for metabolic syndrome. The trial enrolls 40 adults aged 18 to 65 who are not taking medication for blood pressure, blood sugar, or cholesterol. Participants take peppermint oil or a placebo twice daily for a set period, and researchers measure changes in blood pressure, body fat, and other cardiometabolic parameters.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- peppermint oil
- What this could lead to
- If it works, peppermint oil could offer a low-cost, low-risk dietary option to help people with early heart risk factors before they develop full metabolic syndrome.
- What could go wrong
- This is a small, early-stage trial with 40 participants, so any benefits seen may not hold up in larger studies. Peppermint oil can cause heartburn or digestive upset in some people.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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40 people
The number who actually took part.
- Started
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Jan 2025
- Finished
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Sep 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Aged 18-65 years. Meet two of the five metabolic syndrome criteria. Not taking prescribed medication specifically intended to manage blood pressure, blood glucose or blood lipids. Able to complete written questionnaires independently. Able to provide informed consent. Exclusion Criteria: Diagnosed diabetes mellitus. Known cardiovascular disease or clinically significant cardiovascular comorbidity, including coronary heart disease, symptomatic heart failure, clinically significant arrhythmia, or a history of stroke or transient ischaemic attack within the previous six months. Known or suspected secondary hypertension, including renal, renovascular or endocrine causes. Known clinically significant renal impairment or severe hepatic disease. Evidence or history of hypertension-related target-organ damage requiring specialist management. Pregnant or lactating. Allergy or known intolerance to peppermint or any ingredient contained in the intervention or placebo. Habitual consumption of peppermint products. Regular consumption of antioxidant or other dietary supplements likely to influence cardiometabolic outcomes. Body mass index greater than 40.0 kg/m². Current enrolment in another clinical trial or use of another intervention or therapy likely to influence the study outcomes. Any condition likely to compromise informed consent, protocol compliance or outcome assessment, including severe psychiatric illness, cognitive impairment, or active substance or alcohol misuse.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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University of Lancashire
Preston, United Kingdom
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