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Could a common drug plus a supplement help men with infertility?

NCT ID NCT07252518

Disease control Sponsor: Mst.Sumyara Khatun Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether taking pentoxifylline (a drug that improves blood flow) together with coenzyme Q10 (a natural supplement) can increase sperm movement better than CoQ10 alone. Fifty-six men with low sperm motility will take either the combo or just CoQ10 for three months. The goal is to see if the combination leads to more progressive sperm movement, which could improve fertility.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pentoxifylline and coenzyme Q10
What this could lead to
If it works, this could offer a simple, low-cost combination therapy to improve sperm motility in men with low sperm movement.
What could go wrong
This is a small, early-stage trial with only 56 participants, so results may not apply widely. The treatment may not work better than CoQ10 alone, and pentoxifylline can cause side effects like nausea or dizziness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 56 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2025

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 50 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sub fertile men with asthenozoospermia(Total motility20% to less than 42%) according to WHO semen analysis,2021. * Age 20-50 years. Exclusion Criteria: * Severe oligoasthenoteratozoospermia * Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery. * Antioxidants supplmentation in the last 3 months * Drug, alcohol or substance abuse, psycho-sexual abnormalities. * Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage Severe oligoasthenoteratozoospermia * Any medical, endocrine and genetic disorders, history of chemotherapy or radiotherapy, genital infection, genital surgery. * Antioxidants supplmentation in the last 3 months * Drug, alcohol or substance abuse, psycho-sexual abnormalities. * Any known hypersensitivity to xanthine related product, recent cerebral or retinal haemorrhage

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Conditions

The condition(s) this trial relates to.

Asthenozoospermia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Asthenozoospermia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Bangladesh Medical University

    RECRUITING

    Dhaka, Shahbag, 1000, Bangladesh

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