Engineered immune cells take aim at blistering skin disease
NCT ID NCT04422912
First seen Jan 07, 2026 · Last updated Apr 28, 2026 · Updated 16 times
Summary
This study tests two types of modified immune cells (CAR T-cells) in 40 adults with active pemphigus vulgaris, a painful blistering condition. The cells are designed to target and destroy the immune cells causing the disease. The main goal is to check safety and find the right dose. Participants must have failed standard treatments.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
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Locations
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Brigham and Women's Hospital
RECRUITINGBoston, Massachusetts, 02115, United States
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Columbia University
RECRUITINGNew York, New York, 10032, United States
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MD Anderson Texas Medical Center
RECRUITINGHouston, Texas, 77030, United States
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Mount Sinai - Icahn School of Medicine
WITHDRAWNNew York, New York, 10029, United States
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Northwestern University
RECRUITINGChicago, Illinois, 60611, United States
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Stanford University, Dept. of Dermatology
RECRUITINGRedwood City, California, 94063, United States
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UC Davis, Dept. of Dermatology
RECRUITINGSacramento, California, 95816, United States
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UT Southwestern Medical Center, Dept. of Dermatology
RECRUITINGDallas, Texas, 75235, United States
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University of Iowa
RECRUITINGIowa City, Iowa, 52242, United States
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University of North Carolina, Department of Dermatology
WITHDRAWNChapel Hill, North Carolina, 27516, United States
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
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University of Washington
COMPLETEDSeattle, Washington, 98109, United States
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Yale University
RECRUITINGNew Haven, Connecticut, 06520, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
Conditions
Explore the condition pages connected to this study.