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New combo therapy aims to fight recurrent head and neck cancer

NCT ID NCT03546582

First seen Jan 24, 2026 · Last updated Jun 18, 2026 · Updated 25 times

Summary

This study looks at whether adding the drug pembrolizumab to targeted radiation therapy can help people whose head and neck cancer has come back or who have a new tumor in the same area. About 86 adults who cannot have surgery will be randomly assigned to get radiation alone or radiation plus the drug. The goal is to see if the combination keeps the cancer from growing longer.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • Boston Medical Center

    Boston, Massachusetts, 02118, United States

  • Centre Hospitalier de l'université de Montréal

    Montreal, Quebec, H2X 3E4, Canada

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic - Weston

    Weston, Florida, 33331, United States

  • Cross Cancer Institute

    Edmonton, Alberta, T6G 1Z2, Canada

  • Fox Chase Cancer Center

    Philadelphia, Pennsylvania, 19111, United States

  • McGill University

    Montreal, Quebec, H4A 3J1, Canada

  • Medical College of Wisconsin

    Milwaukee, Wisconsin, 53226, United States

  • Moffitt Cancer Center

    Tampa, Florida, 33612, United States

  • Northwell Health

    Lake Success, New York, 11042, United States

  • Ohio State University

    Columbus, Ohio, 43210, United States

  • Penn State Milton S. Hershey Medical Center

    Hershey, Pennsylvania, 17033, United States

  • University of Arizona Cancer Center - North Campus

    Tucson, Arizona, 85719, United States

  • University of Cincinnati Cancer Center - UC Medical Center

    Cincinnati, Ohio, 45219, United States

  • University of Louisville, James Graham Brown Cancer Center

    Louisville, Kentucky, 40202, United States

  • University of Pittsburgh Medical Center Shadyside

    Pittsburgh, Pennsylvania, 15232, United States

  • University of Texas Southwestern

    Dallas, Texas, 75390, United States

  • Washington University St. Louis

    St Louis, Missouri, 63110, United States

Conditions

The condition(s) this trial relates to.

head and neck squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.