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Can pelvic exercises boost estrogen therapy for bladder control?

NCT ID NCT07186985

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study looks at whether adding pelvic floor muscle training to vaginal estrogen therapy helps postmenopausal women with stress urinary incontinence more than estrogen alone. About 115 women will be randomly assigned to either the combined treatment or estrogen-only group. The goal is to see if the combination reduces urine leakage better over 6 months.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pelvic floor muscle training and vaginal estrogen therapy
What this could lead to
If successful, this could offer a more effective non-surgical option for managing stress urinary incontinence in postmenopausal women.
What could go wrong
This is a small, early-stage trial with only 115 participants, so results may not apply to all women. The combination therapy may not prove significantly better than estrogen alone.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 115 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Patients diagnosed with stress urinary incontinence. * Women who have been naturally postmenopausal for at least 1 year or are postmenopausal due to bilateral oophorectomy (surgical removal of both ovaries). * Have had sexual intercourse to ensure feasibility of urogenital tract examination and assessment. * Patients who consent to participate in the study and comply with the treatment protocol, including performing pelvic floor muscle training (PFMT) and completing topical vaginal estrogen therapy. Exclusion Criteria: * Patients with concomitant neurological disorders, urinary tract infections, prior pelvic radiotherapy, or congenital malformations of the lower urinary tract. * Genitourinary malformations or fistulas causing continuous urinary incontinence. * Genitourinary cancers or tumors of the urinary tract. * History of spinal cord injury or central nervous system injury affecting the centers that control urination. * Patients previously treated for stress urinary incontinence (SUI) (surgery, medications, exercises). * Patients with severe heart disease, coronary artery disease, or myocardial ischemia. * Patients with pelvic organ prolapse stage III or higher, unexplained vaginal bleeding, confirmed or suspected breast cancer, or vaginitis. * Presence of premalignant factors or suspected steroid-dependent cancers such as endometrial carcinoma. * History of or current hepatic tumors, or progressive liver or biliary disease. * Coagulation/thrombotic disorders, or a history of thromboembolism or stroke. * Severe hypertriglyceridemia. * Hypersensitivity to any component of vaginally administered estrogen products. * The patient or family members are unable to use a smartphone (Android or iOS) to participate in the monitoring program. * The patient does not agree to participate in the study.

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Conditions

The condition(s) this trial relates to.

female stress incontinence Urinary Incontinence, Stress

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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