New drug targets Hard-to-Treat neuroendocrine cancers
NCT ID NCT05652686
First seen Nov 01, 2025 · Last updated Jun 22, 2026 · Updated 34 times
Summary
This study tests a new drug called peluntamig (PT217) in people with advanced neuroendocrine cancers, such as small cell lung cancer, that have a specific protein called DLL3. The drug is given alone or with chemotherapy or immunotherapy. The trial aims to find the safest dose and see if it shrinks tumors. About 203 participants will take part.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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City of Hope (City of Hope National Medical Center, City of Hope Medical Center)
RECRUITINGDuarte, California, 91010, United States
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Massachusetts General Hospital
RECRUITINGBoston, Massachusetts, 02114, United States
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Mays Cancer Center / University of Texas, San Antonio
RECRUITINGSan Antonio, Texas, 78229, United States
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NEXT Virginia
RECRUITINGFairfax, Virginia, 22031, United States
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Providence Portland Medical Center
RECRUITINGPortland, Oregon, 97213, United States
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Sarah Cannon Research Institute University of Oklahoma
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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Sarah Cannon Research Institute at HealthONE
RECRUITINGDenver, Colorado, 80218, United States
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Sidney Kimmel Comprehensive Cancer Center at John Hopkins
RECRUITINGBaltimore, Maryland, 21287, United States
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The University of Texas, MD Anderson Cancer Center
NOT_YET_RECRUITINGHouston, Texas, 77030, United States
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University of North Carolina at Chapel Hill
RECRUITINGChapel Hill, North Carolina, 27599, United States
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Washington University School of Medicine (Siteman Cancer Center)
RECRUITINGSt Louis, Missouri, 63108, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Peluntamig (PT217), a drug that targets DLL3 and CD47 proteins on cancer cells, given alone or with chemotherapy (carboplatin, etoposide, paclitaxel) or immunotherapy (atezolizumab)
What this could lead to
If successful, this could lead to a new treatment option for aggressive neuroendocrine cancers like small cell lung cancer that are hard to treat.
What could go wrong
This is an early phase 1/2 trial, so safety and effectiveness are not yet proven. The drug may cause side effects or not work as hoped.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.