Peanut allergy mystery: why do some kids outgrow it?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Challenge Inclusion Criteria: CHILD study participants will be eligible for challenge if they 1. Have completed their 5-year-old CHILD Study visit 2. Are or have been sensitized to peanut i.e. have had a positive skin prick test (wheal diameter at least 2 mm greater than the negative control) and/or allergen-specific IgE level (\>0.35 kU/L) to peanut at their 1-, 3- and/or 5-year-old CHILD study visit 3. Are not eating peanut. Children who eat less than 8-10 g of peanut per month or who eat only foods that 'may contain' traces of peanut will still be eligible for inclusion. Challenge Exclusion Criteria: CHILD study participants will be ineligible for challenge if 1. They have never had a positive skin prick test or allergen-specific IgE level to peanut 2. They are eating 8-10 g of peanut at least once per month, despite having had a positive skin prick test or allergen-specific IgE level to peanut 3. Their family has declined to participate 4. They have a peanut skin prick test wheal size \>8mm and/or a peanut-specific IgE \>15 kU/L and a history suggestive of an IgE-mediated allergic reaction to peanut. 5. They have a history of anaphylaxis to peanut or a challenge-proven diagnosis of peanut allergy within the past 1-2 years. 6. They have uncontrolled asthma or any other contraindication to performing a DBPC food challenge on the day of challenge. These children may be rescheduled if their asthma control improves. Blood Draw Inclusion Criteria: CHILD study participants will be eligible for blood draw if they 1. Have completed their 5-year-old CHILD Study visit 2. Are or have been sensitized to peanut i.e. have had a positive skin prick test (wheal diameter at least 2 mm greater than the negative control) and/or allergen-specific IgE level (\>0.35 kU/L) to peanut at their 1-, 3- and/or 5-year-old CHILD study visit Blood Draw Exclusion Criteria: CHILD study participants will be ineligible for blood draw if 1. They have never had a positive skin prick test or allergen-specific IgE level to peanut 2. Their family has declined to participate Immunological analyses of the blood samples are underway now that the 2 sites participating in this portion of the study (University of Manitoba and University of British Columbia) have completed their challenges. Challenges were halted in the spring.