Which PCOS treatment works best for periods? new study aims to find out
NCT ID NCT07242131
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study compares three common treatments—birth control pills, progesterone, and inositol—to see which works best for restoring regular periods in women with PCOS. About 150 women aged 18-40 will take one of the treatments for 6 months. The goal is to find effective options that may be safer for those who cannot take birth control.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 150 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Dec 2025
- Expected to finish
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Jun 2026
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Female participants aged 18 to 40 years. * Diagnosed with polycystic ovary syndrome (PCOS) according to the ESHRE/ASRM (Rotterdam) criteria (presence of at least two of the following: oligo/anovulation, clinical or biochemical hyperandrogenism, polycystic ovarian morphology). * No significant comorbid systemic disease. * Willingness to participate and ability to provide written informed consent. * Regular follow-up availability for at least 6 months. Exclusion Criteria: * Known hepatic, renal, cardiovascular, or endocrine disorders other than PCOS. * Pregnancy or current use of hormonal therapy within the past 3 months. * History of thromboembolic disease, breast cancer, or other contraindications to hormonal treatment. * Inability to adhere to follow-up visits or treatment regimen. * Severe cognitive or communication impairment that prevents proper consent or data collection. * Known allergy or hypersensitivity to any component of the study drugs. * Participation in another interventional study within the past 3 months.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Izmir Bakircay University
RECRUITINGIzmir, Menemen, 35665, Turkey (Türkiye)
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can a Patient's own blood plasma kickstart ovulation in PCOS?
- Could a pancreatic peptide hold clues to PCOS-Related insulin resistance?
- PCOS may fuel fatty liver in teens even after accounting for obesity — a study investigates
- Mind over menstrual pain: could a Four-Week online program ease PCOS symptoms?
- Sugar-Alcohol combo may restore periods in PCOS
- Could a diabetes drug boost pregnancy success in women with PCOS?