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New hope for PCOS: drug combo may improve IVF outcomes

NCT ID NCT07604779

Disease control Sponsor: Beni-Suef University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether adding myoinositol or pioglitazone to metformin improves pregnancy rates in women with PCOS undergoing ICSI (a type of IVF). 150 women will take one of three drug regimens for one month before the procedure. Researchers will track fertilization, pregnancy, and miscarriage rates to find the best approach.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Metformin, myoinositol, and pioglitazone
What this could lead to
If successful, this could identify a better pre-treatment regimen to improve fertilization and pregnancy rates in women with PCOS undergoing ICSI.
What could go wrong
This is a small, early-phase trial with no blinding, so results may not be definitive. Side effects from the drugs are possible, and the study may not lead to a standard treatment.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

20 to 45 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age between 20 and 45years who failed to conceive for \>12 months. * BMI \< 35kg/m2 * Polycystic ovary syndrome women (PCOS) * bilateral patent tubes on hysterosalpingography/laparoscopy Exclusion Criteria: * Male factor infertility * uncontrolled hypo/hyperthyroidism couples.

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Conditions

The condition(s) this trial relates to.

polycystic ovary syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Polycystic ovarian syndrome (PCOS)

Contacts and locations

Locations

  • Beni-Suef University Hospital

    Banī Suwayf, Beni Suweif Governorate, 62521, Egypt

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