Can a new CT scan spot tiny gut lesions that older scans miss?
NCT ID NCT07748923
First seen Aug 06, 2026 · Last updated Aug 11, 2026 · Updated 3 times
Summary
This trial compares two types of CT scans—photon-counting CT (PCCT) and dual-energy CT (DECT)—to see which one is better at finding small gastrointestinal lesions (like tiny growths or thickening in the gut lining). About 1,700 adults who are having a contrast-enhanced abdominal CT and have at least one suspected or confirmed small lesion will be included. The study will check how often each scan detects these lesions, using endoscopy with biopsy as the gold standard, and also look at image quality and how well different doctors agree on what they see.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Contrast-enhanced photon-counting computed tomography (PCCT) compared with energy-integrating detector dual-energy CT (DECT)
- What this could lead to
- If PCCT proves more accurate, it could become the preferred imaging method for detecting small gastrointestinal lesions, potentially reducing missed diagnoses and the need for invasive procedures.
- What could go wrong
- The trial is a comparison study, not a treatment trial, so it won't directly improve outcomes. PCCT may not show a significant advantage over DECT, and its higher cost or limited availability could limit widespread adoption.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
1,762 people
The number who actually took part.
- Started
-
Sep 2023
- Finished
-
May 2026
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
This study includes two cohorts: a retrospective diagnostic-performance cohort and a prospective clinical implementation cohort. Patients underwent contrast-enhanced photon-counting CT (PCCT) or energy-integrating detector dual-energy CT (DECT) for evaluation of suspected small gastrointestinal lesions in a clinical setting.
- Ages
-
18 to 80 years
- Sex
-
Anyone
- Healthy volunteers
-
Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults aged 18-80 years. 2. Patients undergoing contrast-enhanced abdominal CT (photon-counting CT or energy-integrating detector dual-energy CT). 3. At least one endoscopically detected or clinically suspected small gastrointestinal lesion. 4. Lesions confirmed or suspected on endoscopy, pathology, or follow-up imaging. 5. Lesions characterized as mucosal thickening or nodular lesions within predefined size criteria (≤2 cm). Exclusion Criteria: 1. Prior gastrointestinal surgery affecting target evaluation region. 2. Poor or nondiagnostic CT image quality. 3. Incomplete or unavailable endoscopic or histopathological reference standard. 4. Ambiguous lesion localization on endoscopy or imaging. 5. Severe motion artifacts or inadequate bowel distension affecting diagnostic evaluation.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Gastrointestinal lesions are added.
Genom att skicka in godkänner du våra Användarvillkor
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Second Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, 400010, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.