New imaging techniques could unmask silent lung damage in mild asthma
NCT ID NCT07143747
First seen Jul 31, 2026 · Last updated Jul 31, 2026
Summary
This study explores whether advanced imaging can detect subtle airway abnormalities in young adults with mild asthma that standard tests might miss. Participants will undergo two types of lung imaging—hyperpolarized xenon-129 MRI and Technegas SPECT—along with breathing tests and questionnaires. The goal is to see if these imaging techniques reveal more detailed lung function changes and whether they relate to symptoms and quality of life. Findings could lead to better diagnostic tools and more personalized treatment strategies for mild asthma.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Hyperpolarized 129Xe gas and Tc-99m-labeled carbon aerosol (Technegas) for lung imaging
- What this could lead to
- If successful, this could lead to better diagnostic tools that detect subtle lung abnormalities in mild asthma, enabling more personalized treatment.
- What could go wrong
- This is an observational study with a small sample size, so findings may not apply broadly. The imaging techniques are experimental and may not correlate with symptoms or standard tests.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
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About 40 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Mar 2026
- Expected to finish
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Dec 2028
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
Participants will be young adults aged 17 to 35 years with physician-diagnosed mild asthma, consistent with Global Initiative for Asthma (GINA) Step 1 criteria. All participants will be prescribed short-acting bronchodilators for as-needed use only and will have no regular controller medication use. Eligible individuals must be otherwise healthy, non-smokers (or with ≤5 pack-year history and no smoking in the past year), and free from other chronic respiratory diseases. Participants will be recruited from the general population and will undergo a single, comprehensive imaging and lung function assessment visit.
- Ages
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17 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: Participants eligible for inclusion in this study must meet all of the following criteria: 1. Participant diagnosed with mild (GINA1) asthma by physician 2. Participant understands study procedures and is willing to participate in the study as indicated by the participant's signature 3. Provision of written, informed consent prior to any study specific procedures 4. Males and females 17 to 35 years of age 5. Women of childbearing potential (after menarche) must ensure that they are using an effective form of birth control for at least 2 months prior to each imaging visit. Examples of effective birth control include: 1. True sexual abstinence 2. A vasectomized sexual partner 3. Implanon® 4. Female sterilization by tubal occlusion 5. Effective intrauterine device (IUD)/levonogestrel intrauterine system (IUS) 6. Depo-Provera™ injections 7. Oral contraceptive 8. Evra Patch™ 9. Nuvaring™ Exclusion Criteria: Participants fulfilling any of the following criteria are not eligible for inclusion in this study: 1. Participant has an implanted mechanically, electrically, or magnetically activated device or any metal in their body which cannot be removed, including but not limited to pacemakers, neurostimulators, biostimulators, implanted insulin pumps, aneurysm clips, bioprosthesis, artificial limb, metallic fragment or foreign body, shunt, surgical staples (including clips or metallic sutures and/or ear implants) (at the discretion of the MRI Technologist) 2. In the investigator's opinion, subject suffers from any physical, psychological or other condition(s) that might prevent performance of the MRI, CT, or Tc99CImaging, such as severe claustrophobia 3. Participants who are pregnant, breastfeeding or have a positive pregnancy test at initial screening visit 4. Participant is unable to perform spirometry or plethysmography maneuvers 5. Participant is unable to perform MRI and CT breath-hold maneuvers
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Robarts Research Institute; The University of Western Ontario
RECRUITINGLondon, Ontario, N6A 5B7, Canada
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