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Brain zapping study seeks to unravel why Parkinson's patients lose balance

NCT ID NCT06464029

Knowledge-focused Sponsor: University of Minnesota Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 02, 2026 · Last updated Jul 02, 2026

Summary

This study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to examine how nerve pathways from the brain to the legs and trunk are affected in people with Parkinson's disease. Researchers will measure brain activity and link it to walking and balance tests in 160 participants, including those with Parkinson's and healthy older adults. The goal is to better understand the biological causes of postural instability, not to test a treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this research could reveal which brain pathways are responsible for balance problems in Parkinson's, potentially guiding future treatments.
What could go wrong
This is an observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to all people with Parkinson's.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 160 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jun 2024

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Participants with PD will undergo an initial screening for inclusion/exclusion criteria by their clinician based on findings obtained during their routine clinical appointment. Potential control participants will be screened for inclusion/exclusion criteria during an initial phone call.

Ages

45 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: Participants with Parkinson's disease * Diagnosis of idiopathic PD or dystonia as determined by a movement disorders neurologist in accordance with the UK Society Brain Bank diagnostic criteria. * Age 45-80 years. * Able to ambulate independently without the use of an assistive device (e.g. cane) for 50 meters. Healthy Older Adults (Control participants) * Age 45-80 years (this group will be age and sex-matched to the PD group) * Able to ambulate independently without the use of an assistive device (cane or walker) Healthy Young Adults * Age 21-44 years (this group will be age and sex-matched to the PD group) * Able to ambulate independently without the use of an assistive device (cane or walker) Exclusion Criteria: * Subjects who describe a history of a frequent vasovagal syncope (fainting) in response to blood, emotional stress, or sensory triggers. * Subjects who are on anti-coagulant medications. * Any musculoskeletal disorder that affects the ability to stand. * History of seizures, epilepsy, stroke, multiple sclerosis, or traumatic brain injury. * Intracranial metallic or magnetic devices. * Pacemaker or any implanted device. * History of surgery on blood vessels, brain or heart. * Unexplained, recurring headaches or concussion within the last six months. * Moderate to severe hearing impairment. * Subjects who are pregnant. * Dementia diagnosis * Other significant neurological disorders that may affect participation or performance in the study * Implanted deep brain stimulator or other neurosurgeries to treat PD.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Minnesota

    RECRUITING

    Minneapolis, Minnesota, 55455, United States

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