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Parkinson's gene study links sleep problems to worse symptoms

NCT ID NCT04553185

Knowledge-focused Sponsor: University of Exeter Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looked at 733 people with Parkinson's disease to see if certain genetic variations in the AQP4 gene are linked to worse motor, cognitive, and sleep symptoms. Participants provided blood samples, wore sleep monitors, and completed online tests. The goal is to better understand how genes and sleep problems relate to Parkinson's progression.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this study could help identify genetic markers that predict worse symptoms in Parkinson's disease, potentially guiding personalized care.
What could go wrong
This is an observational study, not a treatment trial. It only looks for associations, so it cannot prove cause and effect or lead directly to new therapies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

733 people

The number who actually took part.

Started

Nov 2018

Finished

Apr 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Patients with a diagnosis of Parkinson's disease according to Published Criteria.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * 18-85 years of age * Able to give informed consent * Able to perform online neuropsychological examinations * Diagnosis of PD according to Brain Bank Criteria * No presence or personal or family history of other neurological or psychiatric disorders Exclusion Criteria: * Presence of other neurological disorders and known intracranial co-morbidities such as stroke, haemorrhage, space-occupying lesions * Inability to perform online neuropsychological assessment * Inability to have access to informatics technology to perform the online assessment tests * Inability to travel for the assessments * Native language different from English

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinson disease

Contacts and locations

Locations

  • East Kent University Hospitals NHS Foundation Trust

    Ashford, United Kingdom

  • Lewisham and Greenwich NHS Foundation Trust

    London, United Kingdom

  • Prince Phillip Hospital

    Llanelli, United Kingdom

  • University of Exeter

    Exeter, SE16 7RJ, United Kingdom

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