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Pancakes could help kids outgrow egg allergy faster and safer

NCT ID NCT07192510

Disease control Sponsor: KK Women's and Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested whether eating specially prepared pancakes daily could help children with egg allergy tolerate eggs. 23 children participated, starting with small doses in the hospital and continuing at home. The goal was to see if they could eat a full serving of cooked egg without a reaction, and whether that protection lasted even after stopping pancakes for 6-8 weeks.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
pancake oral immunotherapy (baked egg in pancake form)
What this could lead to
If successful, this could offer a safer and more palatable way to help children with egg allergy tolerate eggs, reducing reaction risks.
What could go wrong
This is a small, early-phase study with only 23 participants, so results may not apply widely. Daily pancake eating may still cause allergic reactions or taste fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

23 people

The number who actually took part.

Started

Apr 2021

Finished

Apr 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

2 to 15 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Allergic to 4.443g egg protein or less, at baseline egg open food challenge OR Convincing clinical reaction to egg within past 6 months (or failed a clinical egg food challenge in last 6 months) AND evidence of current sensitization (positive SPT or egg-specific IgE performed within the last 3 months) Exclusion Criteria: Subjects meeting any of the exclusion criteria at baseline will be excluded from participation. * Required previous admission to an intensive care unit for management of an allergic reaction. * Children with a past history of egg allergy currently consuming egg-containing products other than extensively-heated egg in baked foods (e.g. biscuits, cakes). * Developed severe anaphylaxis to egg or egg-containing products requiring more than 2 adrenaline auto-injectors or intravenous adrenaline infusion. * Poorly controlled asthma within the previous 3 months (as defined by clinician judgement with reference to the ICON guidelines). * Moderate-severe eczema despite appropriate use of emollients (eczema is not otherwise an exclusion criteria). * Clinically significant chronic illness (other than asthma, rhinitis or eczema). * History of symptoms of eosinophilic oesophagitis, irrespective of cause. * Undergoing specific immunotherapy to another allergen and within the first year of treatment. * Receiving anti-IgE therapy, oral immunosuppressants, beta-blocker or ACE inhibitor. * Pregnancy. * Unwilling or unable to fulfil study requirements.

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Conditions

The condition(s) this trial relates to.

Egg Hypersensitivity food allergy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Egg allergy

Contacts and locations

Locations

  • KK Women's and Children's Hospital

    Singapore, Singapore

More trials for these conditions

Other studies related to the condition(s) this trial covers.