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No-Drill cavity fix for kids? gel could replace the scary drill

NCT ID NCT07270458

Symptom relief Sponsor: Cairo University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a gel called Cariclast that softens tooth decay, allowing dentists to remove cavities without a drill. It will involve 24 children aged 4-7 with cavities in their back baby teeth. The goal is to see if this method causes less pain and is more accepted by kids than traditional drilling.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cariclast gel (sodium hypochlorite-based)
What this could lead to
If it works, this could offer a less painful, drill-free way to treat cavities in young children, reducing anxiety and improving their dental experience.
What could go wrong
This is a very small, early-stage trial with only 24 children, so results may not apply to everyone. The gel may not remove all decay or could take longer than drilling.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 24 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Oct 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

4 to 7 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Children: 1. children aged 4-7 years 2. in good general health, and medically free according to parent history. 3. Cooperative patients 4. Children whom their parents will comply with follow-ups. 5. Children whom their parents who accept to sign informed consent Tooth: 1. Broad cavitated occlusal lesion with dentinal involvement 2. (Black's Class I cavity) and occlusal access. 3. Radiograph showing dentinal caries up to two-thirds of the dentinal thickness. 4. The consistency of carious lesions ranges from soft to medium hard. 5. Color of carious lesion ranges from light yellow to brown Exclusion Criteria: * Children: 1. Medically or developmentally compromising conditions 2. Children who will be unable to attend follow-up visits. 3. Children whom their parents refuse to give written formed consent. Teeth: 1. Cases requiring restorative treatment that is not of the Class I variety. 2. Extensively damaged teeth. 3. Radiograph showing dentinal caries of more than two thirds of the dentinal thickness. 4. Caries involving pulp or extending below the gingiva.

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Conditions

The condition(s) this trial relates to.

dental caries

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Dental caries in primary molars

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  2. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

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