New talk therapy shows promise for Grief-Related depression
NCT ID NCT07490691
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested a short therapy called Painhunting for adults in Kazakhstan who felt depressed after a stressful life event, like losing a loved one. 84 people were randomly assigned to get the therapy right away or join a waitlist. The therapy involves up to six one-on-one sessions, and the main goal was to see if it lowered depression scores after two weeks.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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84 people
The number who actually took part.
- Started
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Mar 2026
- Finished
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Jun 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Adults aged 18 years or older. 2. History of at least one adverse life event documented by the List of Threatening Experiences (LTE, lifetime version, Brugha et al., 1985). 3. PHQ-9 score of 10 or above at screening. 4. Able to attend therapy sessions in person or via secure video. 5. Provides written informed consent. Exclusion Criteria: 1. Active suicidal ideation with plan (PHQ-9 item 9 score of 3). 2. Current psychotic symptoms. 3. Currently receiving other psychotherapy at enrollment. 4. Substance dependence requiring medical management. 5. Current or concurrent enrollment in any Painhunting training, educational, workshop, or reading-group program during the trial period or the three months preceding enrollment. (Note: this exclusion criterion is being applied retroactively via a documented audit, following surfacing of a single case of concurrent exposure. See 'Protocol Deviations and Quality Assurance' below.) Eligibility rationale: The prior protocol specified interpersonal loss (bereavement, divorce, relationship dissolution) within a 0 to 180 month window. Amendment 3 broadens this to any adverse life event documented by LTE. The LTE is a 12-item instrument designed specifically for depression research, with lifetime-version adaptations validated in multiple populations. Using LTE as the documentation instrument provides a defensible, research-standard definition of adverse life event exposure and removes the artificial narrowing to interpersonal losses alone.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Painhunting Research Center
Astana, Astana, 010000, Kazakhstan
More trials for these conditions
Other studies related to the condition(s) this trial covers.