Scientists probe mysterious bone pain in rare disorder

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * For patients : * Male or female over 18 years of age with fibrous dysplasia/McCune-Albright syndrome diagnosed by a rheumatologist. * Mentally and legally able to provide informed consent to participate in the study. * Affiliated with a health insurance system. * For healthy volunteers : * Male or female over 18 years of age. * Matched to patients by age and sex. * Mentally and legally able to provide informed consent to participate in the study. * Affiliated with a health insurance system. Exclusion Criteria: * For patients : * Medical and/or surgical history considered by the investigator or delegated physician to be incompatible with study procedures (e.g., amputation or physical limitation preventing completion of pain assessment tests). * Recurrent pain at sites planned for stimulation during thermal and mechanical testing (forearms or palms). * Presence of anxiety and/or depression defined as Hospital Anxiety and Depression Scale (HADS) score \>11. * Use of analgesic medication within the week preceding inclusion. * Use of complementary treatments for analgesic purposes (e.g., vitamins, herbal products, cannabinoids). * Individuals under legal protection (guardianship or trusteeship) or deprived of liberty. * Pregnant or breastfeeding women. * Refusal to participate. * For heathly volunteers : * Medical and/or surgical history considered by the investigator or delegated physician to be incompatible with study procedures (e.g., amputation or physical limitation preventing completion of pain assessment tests). * Presence of sleep disorders defined as Pittsburgh Sleep Quality Index (PSQI) score \>5. * Presence of anxiety and/or depression defined as HADS score \>11. * Use of analgesic medication within the week preceding inclusion. * Use of complementary treatments for analgesic purposes (e.g., vitamins, herbal products, cannabinoids). * Individuals under legal protection (guardianship or trusteeship) or deprived of liberty. * Pregnant or breastfeeding women. * Refusal to participate.