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New beads could ease pain after spine surgery

NCT ID NCT07201987

Symptom relief Sponsor: Ganesh M. Shankar Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether placing special beads containing an antibiotic and pain relievers directly into the surgical site during spine surgery can improve recovery. About 100 adults having lumbar spine surgery will either get beads with just antibiotic or beads with antibiotic plus morphine and bupivacaine. Researchers will measure pain, medication use, and hospital stay length.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
vancomycin, morphine, and bupivacaine in calcium sulfate beads
What this could lead to
If it works, this could offer a new way to manage pain and prevent infection after spine surgery, potentially reducing the need for strong painkillers.
What could go wrong
This is a small, early-phase trial. The beads may not work better than standard care, and there is a risk of allergic reaction or infection.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Jan 2027

An estimate. Start dates often move.

Expected to finish

Jan 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years * Able to understand and provide consent in English * Undergoing elective lumbar spinal decompression and fusion surgery at one or two levels Exclusion Criteria: * History of allergy or hypersensitivity to morphine, bupivacaine, or calcium sulfate. * Active systemic or localized infection at the surgical site. * History of chronic opioid dependence or opioid use disorder (as it may confound pain assessment). * Patients with severe renal or hepatic impairment (due to altered metabolism of analgesics and risk of complications from analgesic side effects). * Pregnant or breastfeeding individuals. * Filling of defects that are intrinsic to the stability of the bony structure * Severe vascular or neurological disease * Uncontrolled diabetes * Severe degenerative bone disease * Hypercalcemia

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Postoperative pain management Spine surgery

How to take part

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  1. The official record

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  2. A doctor treating you

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