Den här översättningen är inte klar ännu. Den här sidan är just nu på engelska.

Gå till den engelska sidan

Cure My Disease

Don't miss your cure!

 Log in / Sign up

Dental pain breakthrough? pills before needle may boost numbing

NCT ID NCT07146997

Symptom relief Sponsor: Zahoor khan Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 26, 2026

Summary

This study tested whether taking ibuprofen and serratiopeptidase before a dental numbing shot helps it work better for people with severe tooth pain from pulpitis. 96 adults were split into four groups: placebo, ibuprofen alone, serratiopeptidase alone, or both. Pain was measured during drilling and root canal steps. The goal is to see if the combination improves numbing success.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
ibuprofen and serratiopeptidase
What this could lead to
If successful, this combination could make dental numbing more reliable for people with severe tooth inflammation, reducing pain during root canal treatment.
What could go wrong
This is a small, completed study. Results may not apply to all patients, and the effect might be modest. Risks include side effects from the medications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 3

Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.

Participants

96 people

The number who actually took part.

Started

Nov 2023

Finished

Nov 2024

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

* Inclusion criteria: * Age group of subjects between 18-45 years * Normal PDL appearance on IOPA * No analgesics taken 12 hours prior to study * Mandibular molars and premolars with deep carious lesion having sign and symptom of symptomatic irreversible pulpitis * Exclusion criteria: * Presence of periapical radiolucency on IOPA * Teeth tender to percussion /traumatic teeth * Allergy to medications/anesthetic solution * Pregnant patient \& systemic illness * Patient in which local anesthesia is not effective in first attempt * Patient not giving consent

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for Symptomatic irreversible pulpitis are added.

Vår säkerhetsrekommendation!

Genom att skicka in godkänner du våra Användarvillkor

Conditions

The condition(s) this trial relates to.

pulpitis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Symptomatic irreversible pulpitis

Contacts and locations

Locations

  • HITEC-IMS Taxila

    Rawalpindi, Punjab Province, 47080, Pakistan

More trials for these conditions

Other studies related to the condition(s) this trial covers.