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Can Acupuncture-Like nerve stimulation ease IVF egg retrieval pain?

NCT ID NCT07212127

Symptom relief Sponsor: First Affiliated Hospital of the Chinese People's Liberation Army Naval Medical University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
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Paused for now. It may or may not start again.
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Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
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Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

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Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
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Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests if a special type of nerve stimulation (TENS-WAA) combined with a painkiller (tramadol) can reduce pain during egg retrieval for IVF. Sixty women will be randomly assigned to receive either the real nerve stimulation or a sham version, both with the painkiller. The goal is to see if the combination provides better pain relief and reduces nausea after the procedure.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2025

An estimate. Start dates often move.

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

21 to 42 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Females aged between 21 and 42 years. * Patients diagnosed with infertility requiring oocyte retrieval for in vitro fertilisation-embryo transfer. * Body Mass Index (BMI) 18.5 ≤ BMI ≤ 29.9 kg/m². * Regular menstrual cycles with ultrasound monitoring demonstrating dominant follicle development and ovulation during the natural cycle; good ovarian reserve: follicle-stimulating hormone (FSH) \< 10 IU/L, antral follicle count (AFC) \> 6, anti-Müllerian hormone (AMH) \> 1.5 ng/ml. * Undergoing ovarian stimulation therapy using follicle-stimulating hormone (FSH) or gonadotropin protocols. * Electing tramadol hydrochloride injection for analgesia during oocyte retrieval. * Voluntary participation with signed written informed consent. Exclusion Criteria: * History of other chronic pain conditions, or prolonged use of opioid medications, history of anaesthetic drug addiction, or chronic alcohol abuse. * Severe pelvic adhesions. * Presence of pacemakers or other implanted medical electronic devices. * Concurrent use of high-frequency surgical equipment, artificial heart-lung machines, medical shortwave therapy, or microwave therapy devices. * Presence of scarring or skin lesions at electrode application sites. * Severe anxiety, depression, or other psychiatric conditions impairing accurate description of sensations, or any other disorders potentially affecting pain perception. * Conditions contraindicating or affecting oocyte retrieval, such as coagulation disorders, acute pelvic inflammation, vaginitis, trichomoniasis, endometriomas, ovarian cysts. * Individuals with laparoscopically and/or ultrasonographically confirmed endometriosis. * Patients with ovarian hyporesponsiveness following conventional ovarian stimulation medication.

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Conditions

The condition(s) this trial relates to.

Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oocyte retrieval for ivf Pain

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • The First Affiliated Hospital of Naval Medical University

    Shanghai, Shanghai Municipality, 200433, China

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