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Could tylenol and ibuprofen replace steroids for sudden injuries?

NCT ID NCT07393503

Symptom relief Sponsor: State University of New York at Buffalo Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two short-term pain relief methods for acute musculoskeletal injuries: a steroid dose pack (methylprednisolone) versus a combination of acetaminophen (Tylenol) and ibuprofen (Motrin). Sixty adults with new injuries (less than 2 weeks old) will take one of the treatments for 6 days and report their pain and function. The goal is to see if the over-the-counter option works as well as the prescription steroid.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Methylprednisolone, Acetaminophen, Ibuprofen
What this could lead to
If this trial succeeds, it could show that a simple over-the-counter pain reliever combination works as well as prescription steroids for acute injuries.
What could go wrong
This is a small pilot study with only 60 participants, so results may not apply to everyone. The study is still enrolling and outcomes are based on self-reported pain, which can vary.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 60 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2025

Expected to finish

Jan 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults 18+ * Able to answer survey questions in English * MSK pain \> 3 on the VAS scale in any body part * Invited to participate by and enrolling clinician Exclusion Criteria: * \> 2 weeks from pain onset * Fractures * Active infections * Anaphylactic reaction to either medication (Oral Steroids, Ibuprofen, and/or Acetaminophen) * Currently taking anti-platelet agents (aspirin \</= 100/mg a day, clopidogrel, etc.) * Chronic Kidney Disease Stage 3 or worse * Uncontrolled diabetes (A1C above 9) * Currently taking oral anti-coagulants * History of bleeding ulcer * Cirrhosis * Taking daily prednisone * Chronic pain syndrome * Chronic pain medication (gabapentin, Lyrica, narcotics, etc.) * Pregnant Patients * Worker's Compensation Patients

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Conditions

The condition(s) this trial relates to.

Musculoskeletal Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Musculoskeletal pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • UBMD Orthopaedics and Sports Medicine (716 Health)

    Buffalo, New York, 14221, United States

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