Can a pill or spray ease pain during fertility testing?
NCT ID NCT07383571
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested two different pain relievers—an oral tablet and a topical spray—against a placebo to see if they reduce pain during hysterosalpingography, an X-ray test for blocked fallopian tubes. 102 women with primary infertility took part. The goal was to find a simple way to make the procedure less painful.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- hyoscine butylbromide (oral) and lidocaine-prilocaine (topical spray)
- What this could lead to
- If effective, these treatments could provide a simple, safe way to reduce pain during a common fertility test, making the procedure more comfortable for women.
- What could go wrong
- This is a small, completed trial with 102 participants, so results may not apply to everyone. Pain relief may be modest or no better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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102 people
The number who actually took part.
- Started
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Oct 2025
- Finished
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Apr 2026
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 40 years
- Sex
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Female participants only
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Women aged 18 to 40 years * Primary infertility * Scheduled to undergo hysterosalpingography as part of routine infertility evaluation * Regular menstrual cycles * Hysterosalpingography scheduled during the early proliferative phase of the menstrual cycle, days 6 to 12 * Negative urine pregnancy test on the day of the procedure * Able to understand and use the 0 to 10 Numerical Rating Scale for Pain assessment Exclusion Criteria: * Secondary infertility * Known hypersensitivity to hyoscine, lidocaine, or prilocaine * Use of systemic analgesics, sedatives, or antispasmodics within 24 hours before hysterosalpingography * Chronic pelvic pain or severe dysmenorrhoea requiring regular analgesia * Active pelvic infection * Known uterine anomaly * Cervical stenosis necessitating anaesthesia * History of contrast allergy * Inability to cooperate with numerical pain scoring * Current pregnancy * Severe systemic disease corresponding to American Society of Anesthesiologists physical status class III or higher
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Algezeera Hospital
Giza, Egypt
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