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New combo may ease post-mastectomy pain without strong drugs

NCT ID NCT07022353

Symptom relief Sponsor: Mansoura University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested whether adding a single dose of the muscle relaxant tizanidine to a nerve block (ESP block) improves pain control after mastectomy. 90 patients were randomly assigned to receive either the nerve block alone or the nerve block plus tizanidine before surgery. The goal was to see if the combination delays the need for extra pain medication and lowers pain scores in the first 24 hours.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
tizanidine (a muscle relaxant) and an erector spinae plane (ESP) nerve block
What this could lead to
If it works, this combination could offer better pain relief after mastectomy, reducing the need for strong opioids and improving recovery.
What could go wrong
This is a small, single-center trial with 90 participants. The results may not apply to all patients, and the nerve block requires skilled placement. Side effects from tizanidine or the block are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

90 people

The number who actually took part.

Started

Jul 2025

Finished

Dec 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. American Society of Anesthesiology (ASA) ІІ patients. 2. Scheduled for unilateral modified radical mastectomy. 3. BMI levels between 18.5- 35 Kg/m2. Exclusion Criteria: 1. Patient's refusal. 2. Altered mental status or un-cooperative patients. 3. History of known sensitivity to the used anesthetics. 4. Bleeding or coagulation diathesis. 5. Infection or redness at the injection site. 6. Cardiac, renal, hepatic, hematological disease, peptic ulcer, gastrointestinal bleeding, and central or peripheral neurological disease. 7. Chronic pain. 8. Participants used analgesics routinely within the last 24 h.

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Conditions

The condition(s) this trial relates to.

agnosia breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mastectomy patient

Contacts and locations

Locations

  • Oncology Centre

    Al Mansurah, Egypt

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