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New study aims to ease pain during IVF egg retrieval

NCT ID NCT07536425

Symptom relief Sponsor: Western Galilee Hospital-Nahariya Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests two common painkillers, indomethacin and paracetamol, given before egg retrieval in IVF. 177 women aged 18-45 will rate their pain after the procedure. The goal is to find a better way to manage pain during this common fertility treatment.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Indomethacin and Paracetamol (Acetaminophen)
What this could lead to
If it works, this could point toward a better way to manage pain during egg retrieval for IVF, making the procedure more comfortable.
What could go wrong
This is a small, early-phase trial testing common painkillers, so the results may not lead to major changes. Some people may have side effects like allergic reactions or stomach issues.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 177 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Apr 2026

An estimate. Start dates often move.

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 45 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Women undergoing oocyte retrieval for IVF or ICSI * Age 18-45 years * ASA physical status classification I or II * Willing and able to provide written informed consent Exclusion Criteria: * Known allergy or hypersensitivity to Indomethacin, any NSAID, or Paracetamol * History of gastrointestinal bleeding or peptic ulceration * Renal impairment (GFR \< 30 ml/min/1.73m² or Creatinine \> 1.04 mg/dL) * Hepatic impairment (ALT \> 55 U/L, AST \> upper limit of normal, ALP \> upper limit of normal, Total Bilirubin \> 1.2 mg/dL, or Albumin \< 3.5 g/dL) * Participation in another clinical trial that may interfere with the outcomes of this study

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Conditions

The condition(s) this trial relates to.

agnosia Pain

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Oocyte retrieval Pain

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Western Galilee Hospital, IVF unit

    Nahariya, Israel

More trials for these conditions

Other studies related to the condition(s) this trial covers.