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Which pain shot works best after ankle surgery? new study aims to find out

NCT ID NCT04575688

Symptom relief Sponsor: Campbell Clinic Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only This study
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two standard pain-relief methods after ankle or hindfoot surgery: a shot of Exparel around the surgical area versus a nerve block with bupivacaine behind the knee. About 100 adults having certain foot or ankle procedures will be enrolled. The goal is to see which approach provides better pain control and allows patients to move their toes sooner.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Exparel (bupivacaine liposome injectable suspension) and bupivacaine
What this could lead to
If one method works better, it could improve pain control and reduce the need for narcotics after ankle or foot surgery.
What could go wrong
This is a small, early-phase study (100 people) comparing two already-used methods, so it may not show a clear winner or change practice widely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 100 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2021

Expected to finish

Feb 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Ankle or hindfoot osteotomy or ankle fracture repair * Surgery scheduled at Campbell Surgery Center (1410 Brierbrook Road, Germantown, TN 38138) * 18-80 years of age * ASA I-III with medical clearances as needed * Fluent ub verbal and written English * Willing and able to comply with study instruction and commit to all follow-up visits for theduration of the study * Willing and able to provide written consent Exclusion Criteria: * Diagnosed with chronic pain syndrome * History of allergic reactions to lidocaine, marcaine, Experal, bupivicaine, or other injectable anesthetic agents * Injury associated with workers' compensation * Surgery to be performed at a hospital * Diagnosed with peripheral neuropathy * Hbg A1C is \> 7 mg/dl in diabetic patients only * Long term (chronic) preoperative narcotic usage

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ankle surgery Foot surgery

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • A

    Germantown, Tennessee, 38138, United States

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