New pain block could reduce opioid use after mastectomy

NCT ID NCT07367568

Symptom relief Sponsor: National Cancer Institute, Egypt Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two types of nerve blocks to control pain after modified radical mastectomy. 110 women will receive either a costotransverse foramen block or an erector spinae plane block, both using the numbing drug bupivacaine. The goal is to see which block reduces the need for morphine and provides better pain relief in the first two days after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance: bupivacaine
What this could lead to: If one block works better, it could mean less pain and less need for strong painkillers after mastectomy.
What could go wrong: This is a small, early-stage trial comparing two established techniques. It may not show a clear winner, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 110 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jan 2026

Expected to finish

Jun 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 65 years

Sex

Female participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adult females \> 18 years and ≤ 65 years old. * American Society of Anesthesiologists (ASA) physical status П-III. * Body mass index (BMI) 18-35 kg/m2. * Scheduled for modified radical mastectomy. Exclusion Criteria: * Known allergy or hypersensitivity to local anesthetic agents. * Active infection at the injection site (e.g., cellulitis, abscess). * Coagulopathy or ongoing anticoagulant/antiplatelet therapy \[International Normalized Ratio (INR) \> 1.5 or platelet count \< 100,000/µL\]. * Severe respiratory, cardiac, hepatic, or renal disease. * Morbid obesity. * Severe cognitive impairment or uncooperative behavior that could interfere with block placement.

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Conditions

The condition(s) this trial relates to.

breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Costotransverse foramen block Erector spinae plane block Modified radical mastectomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

The places running it

1 site. The list below names each one and where it is.
The official record

ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

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A doctor treating you

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New pain block could reduce opioid use after mastectomy

What the study statuses mean