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Pacemaker showdown: new method may boost heart health in block patients

NCT ID NCT07276490

Disease control Sponsor: University of Tartu Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two ways to place a pacemaker in people with heart block (a condition where the heart's electrical signals slow or stop). One method uses standard right ventricular pacing, the other uses conduction system pacing (targeting the heart's natural electrical pathways). Researchers will measure blood pressure, heart function, and quality of life over 12 months in 124 participants from two hospitals in Estonia.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Pacemaker implantation (right ventricular pacing vs. conduction system pacing)
What this could lead to
If conduction system pacing works better, it could improve heart function and quality of life for people with heart block who need a pacemaker.
What could go wrong
This is a moderate-sized trial (124 people) comparing two established techniques, so the differences may be small. Results may not apply to people with other heart conditions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 124 people

The number the study aims to enrol. It can still change while the study runs.

Started

Nov 2025

Expected to finish

Dec 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-80 years * Diagnosis of atrioventricular block * Expected survival \>1 year Exclusion Criteria: * Reduced left ventricular ejection fraction (EF \<45%) * Expected ventricular pacing burden \<20% * Inter-arm systolic blood pressure difference \>15 mmHg * Percutaneous coronary intervention or coronary artery bypass surgery within the last 30 days * Secondary hypertension * Orthostatic hypotension * Clinically significant valvular heart disease * Congenital heart disease * Pulse wave analysis or pulse wave velocity measurement cannot be reliably performed * Pregnancy or breastfeeding * Withdrawal of consent by the subject * Loss of contact during the study

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Conditions

The condition(s) this trial relates to.

atrioventricular block

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Atrioventricular block Conduction system pacing Pacing therapy Right ventricular pacing

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    2 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • North Estonia Medical Centre

    RECRUITING

    Tallinn, Harju, 13419, Estonia

  • Tartu University Hospital

    RECRUITING

    Tartu, Tartu, 50406, Estonia

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